1-(thymin-1-yl)-2,3-O-dibenzoyl-(E)-3-(diethylphosphono)-vinyl-β-D-erythrofuranose

Base Information

Chemical Name:1-(thymin-1-yl)-2,3-O-dibenzoyl-(E)-3-(diethylphosphono)-vinyl-β-D-erythrofuranose
CAS No.:1293981-93-7
Molecular Formula:C₂₉H₃₁N₂O₁₀P
Molecular Weight:598.546
Hs Code.:

Synonyms:1-(thymin-1-yl)-2,3-O-dibenzoyl-(E)-3-(diethylphosphono)-vinyl-β-D-erythrofuranose

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(thymin-1-yl)-2,3-O-dibenzoyl-(E)-3-(diethylphosphono)-vinyl-β-D-erythrofuranose

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Technology Process of 1-(thymin-1-yl)-2,3-O-dibenzoyl-(E)-3-(diethylphosphono)-vinyl-β-D-erythrofuranose

There total 5 articles about 1-(thymin-1-yl)-2,3-O-dibenzoyl-(E)-3-(diethylphosphono)-vinyl-β-D-erythrofuranose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1,2,3-O-tribenzoyl-(E)-3-(diethylphosphono)vinyl-D-erythrofuranose

: 65-71-4,28806-14-6,691841-57-3
thymin

: 1293981-93-7
1-(thymin-1-yl)-2,3-O-dibenzoyl-(E)-3-(diethylphosphono)-vinyl-β-D-erythrofuranose

Guidance literature:: thymin; With ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane; Inert atmosphere; Reflux;

1,2,3-O-tribenzoyl-(E)-3-(diethylphosphono)vinyl-D-erythrofuranose; With tin(IV) chloride; In acetonitrile; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jo200033p

Reference yield:

: 1293981-89-1
1,2-O-isopropylidene-(E)-3-(diethylphosphono)vinyl-α-D-erythrofuranose

: 1293981-93-7
1-(thymin-1-yl)-2,3-O-dibenzoyl-(E)-3-(diethylphosphono)-vinyl-β-D-erythrofuranose

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap; triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / water / 0 - 20 °C

3.1: dmap; triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

4.1: ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane / Inert atmosphere; Reflux

4.2: 1 h / 20 °C / Inert atmosphere

With dmap; ammonium sulfate; triethylamine; 1,1,1,3,3,3-hexamethyl-disilazane; trifluoroacetic acid; In dichloromethane; water;
DOI:10.1021/jo200033p

Reference yield:

: 1293981-90-4
1,2-O-isopropylidene-3-O-benzoyl-(E)-3-(diethylphosphono)vinyl-α-D-erythrofuranose

: 1293981-93-7
1-(thymin-1-yl)-2,3-O-dibenzoyl-(E)-3-(diethylphosphono)-vinyl-β-D-erythrofuranose

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / water / 0 - 20 °C

2.1: dmap; triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

3.1: ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane / Inert atmosphere; Reflux

3.2: 1 h / 20 °C / Inert atmosphere

With dmap; ammonium sulfate; triethylamine; 1,1,1,3,3,3-hexamethyl-disilazane; trifluoroacetic acid; In dichloromethane; water;
DOI:10.1021/jo200033p