Toluene-4-sulfonic acid (1R,3R)-2,2-difluoro-3-phenyl-cyclopropylmethyl ester

Base Information

Chemical Name:Toluene-4-sulfonic acid (1R,3R)-2,2-difluoro-3-phenyl-cyclopropylmethyl ester
CAS No.:81635-04-3
Molecular Formula:C₁₇H₁₆F₂O₃S
Molecular Weight:338.375
Hs Code.:

Synonyms:Toluene-4-sulfonic acid (1R,3R)-2,2-difluoro-3-phenyl-cyclopropylmethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Toluene-4-sulfonic acid (1R,3R)-2,2-difluoro-3-phenyl-cyclopropylmethyl ester

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Technology Process of Toluene-4-sulfonic acid (1R,3R)-2,2-difluoro-3-phenyl-cyclopropylmethyl ester

There total 3 articles about Toluene-4-sulfonic acid (1R,3R)-2,2-difluoro-3-phenyl-cyclopropylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 21040-45-9
Cinnamyl acetate

: 81635-04-3
Toluene-4-sulfonic acid (1R,3R)-2,2-difluoro-3-phenyl-cyclopropylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) pyrolysis, 170 - 180 deg C

2: KOH / methanol; tetrahydrofuran

3: pyridine / CH₂Cl₂

With pyridine; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0040-4039(01)92485-2

Reference yield:

: 82045-06-5
1-(acetoxymethyl)-2,2-difluoro-3-phenylcyclopropane

: 81635-04-3
Toluene-4-sulfonic acid (1R,3R)-2,2-difluoro-3-phenyl-cyclopropylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: KOH / methanol; tetrahydrofuran

2: pyridine / CH₂Cl₂

With pyridine; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0040-4039(01)92485-2