1-methyl-7-methoxy-3,4-diphenylisoquinoline

Base Information

• Chemical Name: 1-methyl-7-methoxy-3,4-diphenylisoquinoline
• CAS No.: 1198575-40-4
• Molecular Formula: C₂₃H₁₉NO
• Molecular Weight: 325.41
• Mol file: 1198575-40-4.mol

Synonyms:1-methyl-7-methoxy-3,4-diphenylisoquinoline

Chemical Property of 1-methyl-7-methoxy-3,4-diphenylisoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 1-methyl-7-methoxy-3,4-diphenylisoquinoline

There total 14 articles about 1-methyl-7-methoxy-3,4-diphenylisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

1-(3-methoxy-phenyl)-ethanone oxime (122806-25-1) + diphenyl acetylene (501-65-5) → 1-methyl-7-methoxy-3,4-diphenylisoquinoline (1198575-40-4)

Guidance literature:

With Wilkinson's catalyst; In toluene; at 130 ℃; for 12h; regioselective reaction; Inert atmosphere;

DOI:10.1021/jo902084j

Reference yield: 76.0%

C17H18N2O3 + diphenyl acetylene (501-65-5) → 1-methyl-7-methoxy-3,4-diphenylisoquinoline (1198575-40-4)

Guidance literature:

With carbonyl(pentamethylcyclopentadienyl)cobalt diiodide; sodium acetate; In 2,2,2-trifluoroethanol; at 110 ℃; for 16h; regioselective reaction;

DOI:10.1080/00397911.2019.1655765

Reference yield: 66.0%

(E)-2-(((1-(3-methoxyphenyl)ethylidene)amino)oxy)-2-methylpropanoic acid + diphenyl acetylene (501-65-5) → 1-methyl-7-methoxy-3,4-diphenylisoquinoline (1198575-40-4)

Guidance literature:

With 2,2,6,6-tetramethylheptane-3,5-dione; cobalt(III) acetylacetonate; 1-Adamantanecarboxylic acid; at 100 ℃; for 12h; Sealed tube;

DOI:10.1021/acs.orglett.9b00866

upstream raw materials:

1-(3-methoxy-phenyl)-ethanone oxime

diphenyl acetylene

(E)-1-(3-methoxyphenyl) ethanone O-acetyl oxime

1-(3-Methoxyphenyl)ethanone