5-(3-{3-[(2S)-2,3-dihydroxypropyl]-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl}-1,2,4-oxadiazol-5-yl)-2-[(1-methylethyl)oxy]benzonitrile

Base Information

Chemical Name:5-(3-{3-[(2S)-2,3-dihydroxypropyl]-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl}-1,2,4-oxadiazol-5-yl)-2-[(1-methylethyl)oxy]benzonitrile
CAS No.:1258852-98-0
Molecular Formula:C₂₅H₂₈N₄O₄
Molecular Weight:448.522
Hs Code.:

Synonyms:5-(3-{3-[(2S)-2,3-dihydroxypropyl]-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl}-1,2,4-oxadiazol-5-yl)-2-[(1-methylethyl)oxy]benzonitrile

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Chemical Property of 5-(3-{3-[(2S)-2,3-dihydroxypropyl]-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl}-1,2,4-oxadiazol-5-yl)-2-[(1-methylethyl)oxy]benzonitrile

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Technology Process of 5-(3-{3-[(2S)-2,3-dihydroxypropyl]-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl}-1,2,4-oxadiazol-5-yl)-2-[(1-methylethyl)oxy]benzonitrile

There total 7 articles about 5-(3-{3-[(2S)-2,3-dihydroxypropyl]-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl}-1,2,4-oxadiazol-5-yl)-2-[(1-methylethyl)oxy]benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 453-17-8,367-47-5,26793-98-6
D-Glyceraldehyde

: 1167415-61-3
2-[(1-methylethyl)oxy]-5-[3-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1,2,4-oxadiazol-5-yl]benzonitrile hydrochloride

: 1258852-98-0
5-(3-{3-[(2S)-2,3-dihydroxypropyl]-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl}-1,2,4-oxadiazol-5-yl)-2-[(1-methylethyl)oxy]benzonitrile

Guidance literature:: D-Glyceraldehyde; 2-[(1-methylethyl)oxy]-5-[3-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1,2,4-oxadiazol-5-yl]benzonitrile hydrochloride; With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;

D-Glyceraldehyde; With acetic acid; In dichloromethane;

Reference yield:

: 258273-31-3
3-cyano-4-isopropoxybenzoic acid

: 1258852-98-0
5-(3-{3-[(2S)-2,3-dihydroxypropyl]-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl}-1,2,4-oxadiazol-5-yl)-2-[(1-methylethyl)oxy]benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / 4 h / 20 °C

2: pyridine / toluene / 1.5 h / 110 °C / Inert atmosphere; Reflux

3: hydrogenchloride / dichloromethane; 1,4-dioxane; diethyl ether / 3.5 h

4: sodium tris(acetoxy)borohydride / dichloromethane / 16 h / 20 °C / Inert atmosphere

With pyridine; hydrogenchloride; oxalyl dichloride; sodium tris(acetoxy)borohydride; N,N-dimethyl-formamide; In 1,4-dioxane; diethyl ether; dichloromethane; toluene;

Reference yield:

: 264264-28-0
1,1-dimethylethyl-7-{[(trifluoromethyl)sulfonyl]oxy}-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate

: 1258852-98-0
5-(3-{3-[(2S)-2,3-dihydroxypropyl]-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl}-1,2,4-oxadiazol-5-yl)-2-[(1-methylethyl)oxy]benzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1.25 h / 100 °C / Inert atmosphere

2: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol / 4 h / 60 °C / Reflux

3: pyridine / toluene / 1.5 h / 110 °C / Inert atmosphere; Reflux

4: hydrogenchloride / dichloromethane; 1,4-dioxane; diethyl ether / 3.5 h

5: sodium tris(acetoxy)borohydride / dichloromethane / 16 h / 20 °C / Inert atmosphere

With pyridine; hydrogenchloride; hydroxylamine hydrochloride; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;