2-[3-benzyloxy-5-(3,5-difluoro-benzyloxy)-phenyl]-4-methyl-pentanoic acid ethyl ester

Base Information

• Chemical Name: 2-[3-benzyloxy-5-(3,5-difluoro-benzyloxy)-phenyl]-4-methyl-pentanoic acid ethyl ester
• CAS No.: 1144593-01-0
• Molecular Formula: C₂₈H₃₀F₂O₄
• Molecular Weight: 468.541

Synonyms:2-[3-benzyloxy-5-(3,5-difluoro-benzyloxy)-phenyl]-4-methyl-pentanoic acid ethyl ester

Chemical Property of 2-[3-benzyloxy-5-(3,5-difluoro-benzyloxy)-phenyl]-4-methyl-pentanoic acid ethyl ester

Chemical Property:

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Technology Process of 2-[3-benzyloxy-5-(3,5-difluoro-benzyloxy)-phenyl]-4-methyl-pentanoic acid ethyl ester

There total 2 articles about 2-[3-benzyloxy-5-(3,5-difluoro-benzyloxy)-phenyl]-4-methyl-pentanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(3-Benzyloxy-5-hydroxy-phenyl)-4-methyl-pentanoic acid ethyl ester (1144593-00-9) + C20H22O4 (1144593-13-4) + C21H24O4 (1144593-11-2) + 1-bromomethyl-3,5-difluoro-benzene (141776-91-2) → 2-[3-benzyloxy-5-(3,5-difluoro-benzyloxy)-phenyl]-4-methyl-pentanoic acid ethyl ester (1144593-01-0) + C27H26F2O4 + C28H28F2O4

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 1h;

Reference yield:

2-(3-Benzyloxy-5-hydroxy-phenyl)-4-methyl-pentanoic acid ethyl ester (1144593-00-9) + C21H24O4 (1144593-11-2) + C20H24O4 + 1-bromomethyl-3,5-difluoro-benzene (141776-91-2) → 2-[3-benzyloxy-5-(3,5-difluoro-benzyloxy)-phenyl]-4-methyl-pentanoic acid ethyl ester (1144593-01-0) + C28H28F2O4 + C27H28F2O4

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 1h;

Reference yield:

2-[3-benzyloxy-5-(3,5-difluoro-benzyloxy)-phenyl]-4-methyl-pentanoic acid ethyl ester (1144593-01-0) → C21H24F2O4 (1144593-04-3)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; for 2h; under 1034.32 Torr;

upstream raw materials:

2-(3-Benzyloxy-5-hydroxy-phenyl)-4-methyl-pentanoic acid ethyl ester

C₂₀H₂₂O₄

C₂₁H₂₄O₄

1-bromomethyl-3,5-difluoro-benzene

Downstream raw materials:

C₂₁H₂₄F₂O₄

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