4-Bromo-benzoic acid 3-((E)-4-acetoxy-2-methyl-but-2-enyloxy)-2-cyanocarbonyl-benzyl ester

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Chemical Name:4-Bromo-benzoic acid 3-((E)-4-acetoxy-2-methyl-but-2-enyloxy)-2-cyanocarbonyl-benzyl ester
CAS No.:857651-87-7
Molecular Formula:C₂₃H₂₀BrNO₆
Molecular Weight:486.319
Hs Code.:

Synonyms:4-Bromo-benzoic acid 3-((E)-4-acetoxy-2-methyl-but-2-enyloxy)-2-cyanocarbonyl-benzyl ester

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Chemical Property of 4-Bromo-benzoic acid 3-((E)-4-acetoxy-2-methyl-but-2-enyloxy)-2-cyanocarbonyl-benzyl ester

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Technology Process of 4-Bromo-benzoic acid 3-((E)-4-acetoxy-2-methyl-but-2-enyloxy)-2-cyanocarbonyl-benzyl ester

There total 7 articles about 4-Bromo-benzoic acid 3-((E)-4-acetoxy-2-methyl-but-2-enyloxy)-2-cyanocarbonyl-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 857652-16-5
4-Bromo-benzoic acid 3-((E)-4-acetoxy-2-methyl-but-2-enyloxy)-2-(cyano-hydroxy-methyl)-benzyl ester

: 857651-87-7
4-Bromo-benzoic acid 3-((E)-4-acetoxy-2-methyl-but-2-enyloxy)-2-cyanocarbonyl-benzyl ester

Guidance literature:: With pyridinium chlorochromate; In dichloromethane; at 40 ℃; for 10h;
DOI:10.1021/ja0509984

Reference yield:

: 857651-83-3
4-Bromo-benzoic acid 3-((E)-4-acetoxy-2-methyl-but-2-enyloxy)-2-formyl-benzyl ester

: 857651-87-7
4-Bromo-benzoic acid 3-((E)-4-acetoxy-2-methyl-but-2-enyloxy)-2-cyanocarbonyl-benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / toluene / 1 h / 0 - 25 °C

2: 62 percent / pyridinium chlorochromate / CH₂Cl₂ / 10 h / 40 °C

With pyridinium chlorochromate; In dichloromethane; toluene;
DOI:10.1021/ja0509984

Reference yield:

: 586-75-4
4-chlorobenzoyl chloride

: 857651-87-7
4-Bromo-benzoic acid 3-((E)-4-acetoxy-2-methyl-but-2-enyloxy)-2-cyanocarbonyl-benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 97 percent / 4-(dimethylamino)pyridine; Et₃N / CH₂Cl₂ / 0.33 h / 25 °C

2: 85 percent / aq. p-TsOH / tetrahydrofuran / 10 h / 75 °C

3: 87 percent / MnO₂ / ethyl acetate / 1.5 h / 25 °C

4: 74 percent / K₂CO₃ / acetone / 2 h / 56 °C

5: 97 percent / toluene / 1 h / 0 - 25 °C

6: 62 percent / pyridinium chlorochromate / CH₂Cl₂ / 10 h / 40 °C

With dmap; manganese(IV) oxide; potassium carbonate; toluene-4-sulfonic acid; triethylamine; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; ethyl acetate; acetone; toluene;
DOI:10.1021/ja0509984