(E)-cinnamyl 5'-phenyl-(2'E,4'E)-pentadienyl sulfone

Base Information

• Chemical Name: (E)-cinnamyl 5'-phenyl-(2'E,4'E)-pentadienyl sulfone
• CAS No.: 444577-97-3
• Molecular Formula: C₂₀H₂₀O₂S
• Molecular Weight: 324.444
• Mol file: 444577-97-3.mol

Synonyms:(E)-cinnamyl 5'-phenyl-(2'E,4'E)-pentadienyl sulfone

Chemical Property of (E)-cinnamyl 5'-phenyl-(2'E,4'E)-pentadienyl sulfone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-cinnamyl 5'-phenyl-(2'E,4'E)-pentadienyl sulfone

There total 5 articles about (E)-cinnamyl 5'-phenyl-(2'E,4'E)-pentadienyl sulfone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

(E)-cinnamyl 5'-phenyl-(2'E,4'E)-pentadienyl sulfide (444577-90-6) → (E)-cinnamyl 5'-phenyl-(2'E,4'E)-pentadienyl sulfone (444577-97-3)

Guidance literature:

With Oxone; In methanol; dichloromethane; at 20 ℃;

DOI:10.1016/S0040-4020(01)01224-8

Reference yield:

(2E,4E)-ethyl 4-methyl-5-phenylpenta-2,4-dienoate (58550-28-0) → (E)-cinnamyl 5'-phenyl-(2'E,4'E)-pentadienyl sulfone (444577-97-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 91 percent / DIBALH / hexane / 1 h / 20 °C

2.1: SOCl₂

3.1: KOH; Na₂S₂O₃*5H₂O / methanol / 0.5 h / 0 °C

3.2: 66 percent / benzene / 1 h / 20 °C

4.1: 70 percent / oxone / CH₂Cl₂; methanol / 20 °C

With Oxone; potassium hydroxide; thionyl chloride; diisobutylaluminium hydride; sodium thiosulfate; In methanol; hexane; dichloromethane;

DOI:10.1016/S0040-4020(01)01224-8

Reference yield:

(2E,4E)-4-methyl-5-phenyl-penta-2,4-dien-1-ol (148601-11-0) → (E)-cinnamyl 5'-phenyl-(2'E,4'E)-pentadienyl sulfone (444577-97-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: SOCl₂

2.1: KOH; Na₂S₂O₃*5H₂O / methanol / 0.5 h / 0 °C

2.2: 66 percent / benzene / 1 h / 20 °C

3.1: 70 percent / oxone / CH₂Cl₂; methanol / 20 °C

With Oxone; potassium hydroxide; thionyl chloride; sodium thiosulfate; In methanol; dichloromethane;

DOI:10.1016/S0040-4020(01)01224-8

upstream raw materials:

(E)-cinnamyl 5'-phenyl-(2'E,4'E)-pentadienyl sulfide

(2E,4E)-ethyl 4-methyl-5-phenylpenta-2,4-dienoate

(2E,4E)-4-methyl-5-phenyl-penta-2,4-dien-1-ol

α-methyl-trans-cinnamaldehyde

Downstream raw materials:

1,8-diphenyl-1,3,5,7-octatetraene