Technology Process of 4,4'-(3-methyltetrahydrofuran-2,2-diyl)bis(2,6-dimethoxyphenol)
There total 13 articles about 4,4'-(3-methyltetrahydrofuran-2,2-diyl)bis(2,6-dimethoxyphenol) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4,4'-(1-hydroxy-2-methylbut-3-ene-1,1-diyl)bis(2,6-dimethoxyphenol);
With
dimethylsulfide borane complex;
In
tetrahydrofuran;
at 0 ℃;
for 6h;
Inert atmosphere;
With
dihydrogen peroxide; sodium hydroxide;
In
tetrahydrofuran; water;
at 20 ℃;
for 6h;
DOI:10.1021/jo1025749
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 0 - 20 °C / Inert atmosphere
2.1: potassium hydroxide / ethanol / 1 h / 20 °C / Inert atmosphere
3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 6.5 h / 0 °C / Inert atmosphere
4.1: dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
5.1: tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere
5.2: 0.08 h / -78 °C / Inert atmosphere
6.1: ammonium chloride; zinc / tetrahydrofuran; water / 1.33 h / 0 °C
7.1: 1,3-dimethylbarbituric acid; palladium diacetate; triphenylphosphine / ethanol / 2 h / 20 °C / Inert atmosphere
8.1: dimethylsulfide borane complex / tetrahydrofuran / 6 h / 0 °C / Inert atmosphere
8.2: 6 h / 20 °C
With
oxalyl dichloride; 1,3-dimethylbarbituric acid; dimethylsulfide borane complex; palladium diacetate; potassium carbonate; ammonium chloride; N,N-dimethyl-formamide; triphenylphosphine; potassium hydroxide; zinc;
In
tetrahydrofuran; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide;
6.1: Barbier reaction;
DOI:10.1021/jo1025749
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: ammonium chloride; zinc / tetrahydrofuran; water / 1.33 h / 0 °C
2.1: 1,3-dimethylbarbituric acid; palladium diacetate; triphenylphosphine / ethanol / 2 h / 20 °C / Inert atmosphere
3.1: dimethylsulfide borane complex / tetrahydrofuran / 6 h / 0 °C / Inert atmosphere
3.2: 6 h / 20 °C
With
1,3-dimethylbarbituric acid; dimethylsulfide borane complex; palladium diacetate; ammonium chloride; triphenylphosphine; zinc;
In
tetrahydrofuran; ethanol; water;
1.1: Barbier reaction;
DOI:10.1021/jo1025749
