3-Chloro-N-(4-chlorophenyl)-propanesulfonamide

Base Information

• Chemical Name: 3-Chloro-N-(4-chlorophenyl)-propanesulfonamide
• CAS No.: 158089-79-3
• Molecular Formula: C₉H₁₁Cl₂NO₂S
• Molecular Weight: 268.164
• Mol file: 158089-79-3.mol

Synonyms:3-Chloro-N-(4-chlorophenyl)-propanesulfonamide

Chemical Property of 3-Chloro-N-(4-chlorophenyl)-propanesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Chloro-N-(4-chlorophenyl)-propanesulfonamide

There total 1 articles about 3-Chloro-N-(4-chlorophenyl)-propanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

3-chloro-n-propanesulfonyl chloride (1633-82-5) + 4-chloro-aniline (106-47-8) → 3-Chloro-N-(4-chlorophenyl)-propanesulfonamide (158089-79-3)

Guidance literature:

With pyridine; at 20 ℃; for 0.75h;

DOI:10.1021/jm9906015

Reference yield:

3-Chloro-N-(4-chlorophenyl)-propanesulfonamide (158089-79-3) → 3-Mercapto-propane-1-sulfonic acid (4-chloro-phenyl)-amide

Guidance literature:

With potassium hydrosulfide; In methanol; ethanol; at 70 ℃; for 1h;

DOI:10.1248/cpb.43.1511

Reference yield:

3-Chloro-N-(4-chlorophenyl)-propanesulfonamide (158089-79-3) → 3-(Imidazo[1,2-b]pyridazin-6-ylsulfanyl)-propane-1-sulfonic acid (4-chloro-phenyl)-amide

Guidance literature:

Multi-step reaction with 2 steps

1: KSH / methanol; ethanol / 1 h / 70 °C

2: NaOMe / methanol / 1.5 h / 100 °C

With sodium methylate; potassium hydrosulfide; In methanol; ethanol;

DOI:10.1248/cpb.43.1511

upstream raw materials:

3-chloro-n-propanesulfonyl chloride

4-chloro-aniline

Refernces

• 1、 Inagaki, Masanao,Tsuri, Tatsuo,Jyoyama, Hirokuni,Ono, Takashi,Yamada, Katsutoshi,Kobayashi, Mika,Hori, Yozo,Arimura, Akinori,Yasui, Kiyoshi,Ohno, Kouji,Kakudo, Shinji,Koizumi, Kenzo,Suzuki, Ryuji,Kato, Miyako,Kawai, Shinichi,Matsumoto, Saichi. "Novel antiarthritic agents with 1,2-isothiazolidine-1-,1-dioxide (γ- sultam) skeleton: Cytokine suppressive dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase". . p. 2040 - 2048. Retrieved 2007/10/03.
• 2、 Kuwahara,Kato,Sugawara,Miyake. "Synthetic studies on condensed-azole derivatives. II. Application of a computer-assisted automated synthesis apparatus for the synthesis of N- substituted sulfamoylpropylthioimidazo[1,2-b]pyridazines". . p. 1511 - 1515. Retrieved 2007/10/03.