- Chemical Name:1,2,3,4-Tetrahydro-4-[2-(1-carboxy-3-carbamoylpropylimino)ethylidene]-2,6-pyridinedicarboxylic acid
- CAS No.:904-62-1
- Molecular Formula:C14H17N3O7
- Molecular Weight:339.3007
- Hs Code.:
- Mol file:904-62-1.mol
Synonyms:Vulgaxanthin-I;
Synonyms:Vulgaxanthin-I;
99% *data from raw suppliers
The research presents a versatile and efficient method for synthesizing α,α'-disubstituted N-hydroxypiperidines and N-hydroxypyrrolidines through a double 1,4-addition of hydroxylamine to bis α,β-unsaturated diesters. The synthesis occurs in an environmentally friendly ethanol/water system at room temperature. Key chemicals involved include octa-2,6-dienedioic acid diethyl ester and nona-2,6-dienedioic acid diethyl ester, which are synthesized from succinaldehyde or glutaraldehyde. Hydroxylamine is used for the double 1,4-addition, yielding N-hydroxypyrrolidines and N-hydroxypiperidines with good selectivity for the cis isomers. The study also explores the behavior of the double 1,4-addition in systems containing a ketone, revealing that the keto group can be selectively converted to either an oxime or an N-hydroxy compound by adjusting the amount of hydroxylamine.