dimethyl (4S,7S,10aS,4'S,7'S,10a'S)-4,4'-(((2R,5R)-2,5-dibenzyl-1,6-dioxo-1,6-hexanediyl)diimino)bis(5-oxooctahydro-7H-pyrido[2,1-b][1,3]thiazepine-7-carboxylate)

Base Information

Chemical Name:dimethyl (4S,7S,10aS,4'S,7'S,10a'S)-4,4'-(((2R,5R)-2,5-dibenzyl-1,6-dioxo-1,6-hexanediyl)diimino)bis(5-oxooctahydro-7H-pyrido[2,1-b][1,3]thiazepine-7-carboxylate)
CAS No.:1400674-83-0
Molecular Formula:C₄₂H₅₄N₄O₈S₂
Molecular Weight:807.045
Hs Code.:

dimethyl (4S,7S,10aS,4'S,7'S,10a'S)-4,4'-(((2R,5R)-2,5-dibenzyl-1,6-dioxo-1,6-hexanediyl)diimino)bis(5-oxooctahydro-7H-pyrido[2,1-b][1,3]thiazepine-7-carboxylate)

Synonyms:dimethyl (4S,7S,10aS,4'S,7'S,10a'S)-4,4'-(((2R,5R)-2,5-dibenzyl-1,6-dioxo-1,6-hexanediyl)diimino)bis(5-oxooctahydro-7H-pyrido[2,1-b][1,3]thiazepine-7-carboxylate)

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Chemical Property of dimethyl (4S,7S,10aS,4'S,7'S,10a'S)-4,4'-(((2R,5R)-2,5-dibenzyl-1,6-dioxo-1,6-hexanediyl)diimino)bis(5-oxooctahydro-7H-pyrido[2,1-b][1,3]thiazepine-7-carboxylate)

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Technology Process of dimethyl (4S,7S,10aS,4'S,7'S,10a'S)-4,4'-(((2R,5R)-2,5-dibenzyl-1,6-dioxo-1,6-hexanediyl)diimino)bis(5-oxooctahydro-7H-pyrido[2,1-b][1,3]thiazepine-7-carboxylate)

There total 3 articles about dimethyl (4S,7S,10aS,4'S,7'S,10a'S)-4,4'-(((2R,5R)-2,5-dibenzyl-1,6-dioxo-1,6-hexanediyl)diimino)bis(5-oxooctahydro-7H-pyrido[2,1-b][1,3]thiazepine-7-carboxylate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1400675-98-0
(2S,5S,E)-2,5-dibenzyl-1,6-bis((S)-4-benzyl-2-oxooxazolidin-3-yl)hex-3-ene-1,6-dione

: 1400674-83-0
dimethyl (4S,7S,10aS,4'S,7'S,10a'S)-4,4'-(((2R,5R)-2,5-dibenzyl-1,6-dioxo-1,6-hexanediyl)diimino)bis(5-oxooctahydro-7H-pyrido[2,1-b][1,3]thiazepine-7-carboxylate)

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 3 h

2.1: dihydrogen peroxide; lithium hydroxide monohydrate / water; tetrahydrofuran / 0.67 h / 0 °C

2.2: pH < 2

3.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C

With lithium hydroxide monohydrate; hydrogen; dihydrogen peroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 29311-53-3
(E)-3-hexene-1,6-dioic acid

: 1400674-83-0
dimethyl (4S,7S,10aS,4'S,7'S,10a'S)-4,4'-(((2R,5R)-2,5-dibenzyl-1,6-dioxo-1,6-hexanediyl)diimino)bis(5-oxooctahydro-7H-pyrido[2,1-b][1,3]thiazepine-7-carboxylate)

Guidance literature:: Multi-step reaction with 5 steps

1.1: pivaloyl chloride; 4-methyl-morpholine / tetrahydrofuran / 0.5 h / 0 - 20 °C

1.2: 2.75 h / -78 - 20 °C

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.33 h / -78 °C

2.2: 3 h / 20 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 3 h

4.1: dihydrogen peroxide; lithium hydroxide monohydrate / water; tetrahydrofuran / 0.67 h / 0 °C

4.2: pH < 2

5.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C

With 4-methyl-morpholine; lithium hydroxide monohydrate; hydrogen; dihydrogen peroxide; sodium hexamethyldisilazane; pivaloyl chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1400675-96-8
(E)-1,6-bis((S)-4-benzyl-2-oxooxazolidin-3-yl)hex-3-ene-1,6-dione

: 1400674-83-0
dimethyl (4S,7S,10aS,4'S,7'S,10a'S)-4,4'-(((2R,5R)-2,5-dibenzyl-1,6-dioxo-1,6-hexanediyl)diimino)bis(5-oxooctahydro-7H-pyrido[2,1-b][1,3]thiazepine-7-carboxylate)

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.33 h / -78 °C

1.2: 3 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 3 h

3.1: dihydrogen peroxide; lithium hydroxide monohydrate / water; tetrahydrofuran / 0.67 h / 0 °C

3.2: pH < 2

4.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C

With lithium hydroxide monohydrate; hydrogen; dihydrogen peroxide; sodium hexamethyldisilazane; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;