{4-[(S)-2-((1S,2S)-3-{2-[Bis-(2-hydroxy-ethyl)-amino]-ethylcarbamoyl}-1-cyclohexylmethyl-2-hydroxy-propylcarbamoyl)-2-tert-butoxycarbonylamino-ethyl]-thiazol-2-yl}-carbamic acid benzyl ester

Base Information

Chemical Name:{4-[(S)-2-((1S,2S)-3-{2-[Bis-(2-hydroxy-ethyl)-amino]-ethylcarbamoyl}-1-cyclohexylmethyl-2-hydroxy-propylcarbamoyl)-2-tert-butoxycarbonylamino-ethyl]-thiazol-2-yl}-carbamic acid benzyl ester
CAS No.:135704-28-8
Molecular Formula:C₃₆H₅₆N₆O₉S
Molecular Weight:748.941
Hs Code.:

{4-[(S)-2-((1S,2S)-3-{2-[Bis-(2-hydroxy-ethyl)-amino]-ethylcarbamoyl}-1-cyclohexylmethyl-2-hydroxy-propylcarbamoyl)-2-tert-butoxycarbonylamino-ethyl]-thiazol-2-yl}-carbamic acid benzyl ester

Synonyms:{4-[(S)-2-((1S,2S)-3-{2-[Bis-(2-hydroxy-ethyl)-amino]-ethylcarbamoyl}-1-cyclohexylmethyl-2-hydroxy-propylcarbamoyl)-2-tert-butoxycarbonylamino-ethyl]-thiazol-2-yl}-carbamic acid benzyl ester

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Chemical Property of {4-[(S)-2-((1S,2S)-3-{2-[Bis-(2-hydroxy-ethyl)-amino]-ethylcarbamoyl}-1-cyclohexylmethyl-2-hydroxy-propylcarbamoyl)-2-tert-butoxycarbonylamino-ethyl]-thiazol-2-yl}-carbamic acid benzyl ester

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Technology Process of {4-[(S)-2-((1S,2S)-3-{2-[Bis-(2-hydroxy-ethyl)-amino]-ethylcarbamoyl}-1-cyclohexylmethyl-2-hydroxy-propylcarbamoyl)-2-tert-butoxycarbonylamino-ethyl]-thiazol-2-yl}-carbamic acid benzyl ester

There total 4 articles about {4-[(S)-2-((1S,2S)-3-{2-[Bis-(2-hydroxy-ethyl)-amino]-ethylcarbamoyl}-1-cyclohexylmethyl-2-hydroxy-propylcarbamoyl)-2-tert-butoxycarbonylamino-ethyl]-thiazol-2-yl}-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 135704-31-3
(3S,4S)-4-Amino-5-cyclohexyl-3-hydroxy-pentanoic acid {2-[bis-(2-hydroxy-ethyl)-amino]-ethyl}-amide

: 135704-24-4
N-<(1,1-dimethylethoxy)carbonyl>-3-<2-<<(phenylmethoxy)carbonyl>amino>-4-thiazolyl>-L-alanine

: 135704-28-8
{4-[(S)-2-((1S,2S)-3-{2-[Bis-(2-hydroxy-ethyl)-amino]-ethylcarbamoyl}-1-cyclohexylmethyl-2-hydroxy-propylcarbamoyl)-2-tert-butoxycarbonylamino-ethyl]-thiazol-2-yl}-carbamic acid benzyl ester

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1021/jm00092a006

Reference yield:

: 135704-30-2
(S)-3-(2-Amino-thiazol-4-yl)-2-tert-butoxycarbonylamino-propionic acid benzyl ester

: 135704-28-8
{4-[(S)-2-((1S,2S)-3-{2-[Bis-(2-hydroxy-ethyl)-amino]-ethylcarbamoyl}-1-cyclohexylmethyl-2-hydroxy-propylcarbamoyl)-2-tert-butoxycarbonylamino-ethyl]-thiazol-2-yl}-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: aq. sodium bicarbonate / tetrahydrofuran; CH₂Cl₂ / Ambient temperature

2: 80 percent / aq. KOH / ethanol / 4 h / Ambient temperature

3: N-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC) / dimethylformamide / 0 - 20 °C

With potassium hydroxide; sodium hydrogencarbonate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00092a006

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 135704-28-8
{4-[(S)-2-((1S,2S)-3-{2-[Bis-(2-hydroxy-ethyl)-amino]-ethylcarbamoyl}-1-cyclohexylmethyl-2-hydroxy-propylcarbamoyl)-2-tert-butoxycarbonylamino-ethyl]-thiazol-2-yl}-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: aq. sodium bicarbonate / tetrahydrofuran; CH₂Cl₂ / Ambient temperature

2: 80 percent / aq. KOH / ethanol / 4 h / Ambient temperature

3: N-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC) / dimethylformamide / 0 - 20 °C

With potassium hydroxide; sodium hydrogencarbonate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00092a006