3-tetrahydropyran-2-yloxy-2,2,4,4-tetramethyl-1-(4-trifluoromethoxyphenyl)cyclobutanol

Base Information

Chemical Name:3-tetrahydropyran-2-yloxy-2,2,4,4-tetramethyl-1-(4-trifluoromethoxyphenyl)cyclobutanol
CAS No.:283168-40-1
Molecular Formula:C₂₀H₂₇F₃O₄
Molecular Weight:388.427
Hs Code.:

Synonyms:3-tetrahydropyran-2-yloxy-2,2,4,4-tetramethyl-1-(4-trifluoromethoxyphenyl)cyclobutanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-tetrahydropyran-2-yloxy-2,2,4,4-tetramethyl-1-(4-trifluoromethoxyphenyl)cyclobutanol

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Technology Process of 3-tetrahydropyran-2-yloxy-2,2,4,4-tetramethyl-1-(4-trifluoromethoxyphenyl)cyclobutanol

There total 1 articles about 3-tetrahydropyran-2-yloxy-2,2,4,4-tetramethyl-1-(4-trifluoromethoxyphenyl)cyclobutanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 33017-55-9
2,2,4,4-Tetramethyl-3-tetrahydropyran-2-yloxy-cyclobutan-1-on

: 407-14-7
1-bromo-4-(trifluoromethoxy)benzene

: 283168-40-1
3-tetrahydropyran-2-yloxy-2,2,4,4-tetramethyl-1-(4-trifluoromethoxyphenyl)cyclobutanol

Guidance literature:: 1-bromo-4-(trifluoromethoxy)benzene; With magnesium;

2,2,4,4-Tetramethyl-3-tetrahydropyran-2-yloxy-cyclobutan-1-on; In tetrahydrofuran; at 50 ℃; for 3h;
DOI:10.1002/(sici)1521-3897(200004)342:4<409::aid-prac409>3.0.co;2-e

Reference yield:

: 283168-40-1
3-tetrahydropyran-2-yloxy-2,2,4,4-tetramethyl-1-(4-trifluoromethoxyphenyl)cyclobutanol

: 2,2,4,4-tetramethyl-1-(4-trifluoromethoxy-phenyl)-cyclobutane-1,3-diol

Guidance literature:: With toluene-4-sulfonic acid; In methanol;
DOI:10.1002/(sici)1521-3897(200004)342:4<409::aid-prac409>3.0.co;2-e

Reference yield:

: 283168-40-1
3-tetrahydropyran-2-yloxy-2,2,4,4-tetramethyl-1-(4-trifluoromethoxyphenyl)cyclobutanol

: 3-hydroxy-2,2,4,4-tetramethyl-3-(4-trifluoromethoxyphenyl)cyclobutanone

Guidance literature:: Multi-step reaction with 2 steps

1: p-TsOH / methanol

2: oxalyl chloride; DMSO; Et₃N / -70 - 20 °C

With oxalyl dichloride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; In methanol; 1: solvolysis / 2: Swern oxidation;
DOI:10.1002/(sici)1521-3897(200004)342:4<409::aid-prac409>3.0.co;2-e