(S)-N₄-hydroxy-2-isobutyl-N₁-((S)-1-(methylamino)-1-oxo-4-phenylbutan-2-yl)succinamide

Base Information

• Chemical Name: (S)-N₄-hydroxy-2-isobutyl-N₁-((S)-1-(methylamino)-1-oxo-4-phenylbutan-2-yl)succinamide
• CAS No.: 927828-00-0
• Molecular Formula: C₁₉H₂₉N₃O₄
• Molecular Weight: 363.457
• Mol file: 927828-00-0.mol

Synonyms:(S)-N₄-hydroxy-2-isobutyl-N₁-((S)-1-(methylamino)-1-oxo-4-phenylbutan-2-yl)succinamide

Chemical Property of (S)-N₄-hydroxy-2-isobutyl-N₁-((S)-1-(methylamino)-1-oxo-4-phenylbutan-2-yl)succinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N₄-hydroxy-2-isobutyl-N₁-((S)-1-(methylamino)-1-oxo-4-phenylbutan-2-yl)succinamide

There total 3 articles about (S)-N₄-hydroxy-2-isobutyl-N₁-((S)-1-(methylamino)-1-oxo-4-phenylbutan-2-yl)succinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

(2S)-2-isobutyl-N1-((S)-1-(methylamino)-1-oxo-4-phenylbutan-2-yl)-N4-(tetrahydro-2H-pyran-2-yloxy)succinamide (927828-15-7) + (2S)-2-isobutyl-N4-((S)-1-(methylamino)-1-oxo-4-phenylbutan-2-yl)-N1-(tetrahydro-2H-pyran-2-yloxy)succinamide (927828-16-8) → (S)-N4-hydroxy-2-isobutyl-N1-((S)-1-(methylamino)-1-oxo-4-phenylbutan-2-yl)succinamide (927828-00-0)

Guidance literature:

With Amberlyst H-15 resin; In methanol; at 20 ℃; for 3h;

Reference yield: 32.0%

(2S)-2-isobutyl-N1-((S)-1-(methylamino)-1-oxo-4-phenylbutan-2-yl)-N4-(tetrahydro-2H-pyran-2-yloxy)succinamide (927828-15-7) → (S)-N4-hydroxy-2-isobutyl-N1-((S)-1-(methylamino)-1-oxo-4-phenylbutan-2-yl)succinamide (927828-00-0)

Guidance literature:

With methanol; at 20 ℃; for 3h; Product distribution / selectivity;

Reference yield: 4.5%

→ (S)-N4-hydroxy-2-isobutyl-N1-((S)-1-(methylamino)-1-oxo-4-phenylbutan-2-yl)succinamide (927828-00-0)

Guidance literature:

upstream raw materials:

(2S)-2-isobutyl-N₁-((S)-1-(methylamino)-1-oxo-4-phenylbutan-2-yl)-N₄-(tetrahydro-2H-pyran-2-yloxy)succinamide

(2S)-2-isobutyl-N₄-((S)-1-(methylamino)-1-oxo-4-phenylbutan-2-yl)-N₁-(tetrahydro-2H-pyran-2-yloxy)succinamide