Technology Process of (6R,8Z,27Z,30Z)-6-(tert-butyldiphenylsilyloxy)hexatriaconta-8,27,30-trien-18-ol
There total 5 articles about (6R,8Z,27Z,30Z)-6-(tert-butyldiphenylsilyloxy)hexatriaconta-8,27,30-trien-18-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(Z,Z)-octadeca-9,12-dienyl bromide;
With
magnesium;
In
tetrahydrofuran;
at 55 ℃;
for 2h;
Inert atmosphere;
(R,Z)-12-(tert-butyldiphenylsilyloxy)octadec-9-enal;
In
tetrahydrofuran;
at 20 ℃;
for 1.16667h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium carbonate; pyridinium chlorochromate / dichloromethane / 3 h / 20 °C
2.1: magnesium / tetrahydrofuran / 2 h / 55 °C / Inert atmosphere
2.2: 1.17 h / 20 °C
With
sodium carbonate; magnesium; pyridinium chlorochromate;
In
tetrahydrofuran; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: pyridine; silver nitrate / tetrahydrofuran / 1.5 h / 20 °C / Inert atmosphere
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 20 °C / Inert atmosphere
3.1: sodium carbonate; pyridinium chlorochromate / dichloromethane / 3 h / 20 °C
4.1: magnesium / tetrahydrofuran / 2 h / 55 °C / Inert atmosphere
4.2: 1.17 h / 20 °C
With
pyridine; lithium aluminium tetrahydride; sodium carbonate; silver nitrate; magnesium; pyridinium chlorochromate;
In
tetrahydrofuran; dichloromethane;
