7-methyl-5,8-dioxo-6-(4-(trifluoromethyl)benzyl)-5,8-dihydronaphthalen-2-yl trifluoromethanesulfonate

Base Information

Chemical Name:7-methyl-5,8-dioxo-6-(4-(trifluoromethyl)benzyl)-5,8-dihydronaphthalen-2-yl trifluoromethanesulfonate
CAS No.:1402041-36-4
Molecular Formula:C₂₀H₁₂F₆O₅S
Molecular Weight:478.369
Hs Code.:

Synonyms:7-methyl-5,8-dioxo-6-(4-(trifluoromethyl)benzyl)-5,8-dihydronaphthalen-2-yl trifluoromethanesulfonate

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Chemical Property of 7-methyl-5,8-dioxo-6-(4-(trifluoromethyl)benzyl)-5,8-dihydronaphthalen-2-yl trifluoromethanesulfonate

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Technology Process of 7-methyl-5,8-dioxo-6-(4-(trifluoromethyl)benzyl)-5,8-dihydronaphthalen-2-yl trifluoromethanesulfonate

There total 4 articles about 7-methyl-5,8-dioxo-6-(4-(trifluoromethyl)benzyl)-5,8-dihydronaphthalen-2-yl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 32857-62-8
4-Trifluoromethylphenylacetic acid

: 1402041-06-8
7-methyl-5,8-dioxo-5,8-dihydronaphthalen-2-yl trifluoromethanesulfonate

: 1402041-36-4
7-methyl-5,8-dioxo-6-(4-(trifluoromethyl)benzyl)-5,8-dihydronaphthalen-2-yl trifluoromethanesulfonate

Guidance literature:: With 2H₃N*H₂O₄S₂; silver nitrate; In water; acetonitrile; at 70 - 85 ℃;
DOI:10.1002/ejoc.201600144

Reference yield:

: 13321-74-9
1-bromo-2,5-dimethoxy-4-methylbenzene

: 1402041-36-4
7-methyl-5,8-dioxo-6-(4-(trifluoromethyl)benzyl)-5,8-dihydronaphthalen-2-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium cerium (IV) nitrate / water; acetonitrile / 0.5 h / 20 °C

2.1: dichloromethane / 2 h / 0 - 20 °C

2.2: 6 h / 20 °C

3.1: pyridine / dichloromethane / 0.17 h / 20 °C / Inert atmosphere

3.2: 2 h / 20 °C / Inert atmosphere

4.1: silver nitrate; 2H₃N*H₂O₄S₂ / water; acetonitrile / 70 - 85 °C

With pyridine; ammonium cerium (IV) nitrate; 2H₃N*H₂O₄S₂; silver nitrate; In dichloromethane; water; acetonitrile; 4.1: |Kochi Cross Coupling;
DOI:10.1002/ejoc.201600144

Reference yield:

: 13070-25-2
2-bromo-5-methyl-[1,4]benzoquinone

: 1402041-36-4
7-methyl-5,8-dioxo-6-(4-(trifluoromethyl)benzyl)-5,8-dihydronaphthalen-2-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloromethane / 2 h / 0 - 20 °C

1.2: 6 h / 20 °C

2.1: pyridine / dichloromethane / 0.17 h / 20 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

3.1: silver nitrate; 2H₃N*H₂O₄S₂ / water; acetonitrile / 70 - 85 °C

With pyridine; 2H₃N*H₂O₄S₂; silver nitrate; In dichloromethane; water; acetonitrile; 3.1: |Kochi Cross Coupling;
DOI:10.1002/ejoc.201600144