C₃₁H₂₈FN₅O₄

Base Information

• Chemical Name: C₃₁H₂₈FN₅O₄
• CAS No.: 1613589-63-1
• Molecular Formula: C₃₁H₂₈FN₅O₄
• Molecular Weight: 553.593
• Mol file: 1613589-63-1.mol

Synonyms:C₃₁H₂₈FN₅O₄

Chemical Property of C₃₁H₂₈FN₅O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₁H₂₈FN₅O₄

There total 12 articles about C₃₁H₂₈FN₅O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

C31H29FIN5O4 (1613589-62-0) → C31H28FN5O4 (1613589-63-1)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; for 4h; Reflux;

Reference yield:

((2R,3R,4R)-3-benzoyloxy-4-fluoro-4-methyl-5-oxo-tetrahydrofuran-2-yl)methyl benzoate (874638-80-9,1033394-94-3) → C31H28FN5O4 (1613589-63-1)

Guidance literature:

Multi-step reaction with 6 steps

1.1: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / 1 h / -78 - -20 °C / Inert atmosphere

2.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 0.33 h / -25 - -20 °C / Inert atmosphere

3.1: potassium tert-butylate / acetonitrile; tert-butyl alcohol / 0.5 h / 35 °C

3.2: 50 °C

4.1: silver nitrate / dichloromethane / 20 °C

4.2: 12 h / 20 °C

5.1: triphenylphosphine; pyridine; iodine / 20 °C

6.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 4 h / Reflux

With pyridine; carbon tetrabromide; potassium tert-butylate; iodine; silver nitrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium tri-t-butoxyaluminum hydride; triphenylphosphine; In tetrahydrofuran; dichloromethane; acetonitrile; tert-butyl alcohol;

Reference yield:

(((2R,3R,4R,5R)-3-(benzoyloxy)-5-bromo-4-fluoro-4-methyltetrahydrofuran-2-yl)methyl benzoate) (1199809-24-9) → C31H28FN5O4 (1613589-63-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium tert-butylate / acetonitrile; tert-butyl alcohol / 0.5 h / 35 °C

1.2: 50 °C

2.1: silver nitrate / dichloromethane / 20 °C

2.2: 12 h / 20 °C

3.1: triphenylphosphine; pyridine; iodine / 20 °C

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 4 h / Reflux

With pyridine; potassium tert-butylate; iodine; silver nitrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; In tetrahydrofuran; dichloromethane; acetonitrile; tert-butyl alcohol;

upstream raw materials:

((2R,3R,4R)-3-benzoyloxy-4-fluoro-4-methyl-5-oxo-tetrahydrofuran-2-yl)methyl benzoate

(((2R,3R,4R,5R)-3-(benzoyloxy)-5-bromo-4-fluoro-4-methyltetrahydrofuran-2-yl)methyl benzoate)

(2R,3R,4R,5R)-5-(2-amino-6-chloro-9H-purin-9-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate

C₃₁H₃₀FN₅O₅

Downstream raw materials:

C₃₁H₂₈F₂IN₅O₄

C₃₁H₂₉F₂N₅O₅