(2E,4Z)-1-(3-bromo-2-hydroxy-4,6-dimethoxyphenyl)-5-chloro-5-(4-fluoro phenyl)penta-2,4-dien-1-one

Base Information

Chemical Name:(2E,4Z)-1-(3-bromo-2-hydroxy-4,6-dimethoxyphenyl)-5-chloro-5-(4-fluoro phenyl)penta-2,4-dien-1-one
CAS No.:1374843-22-7
Molecular Formula:C₁₉H₁₅BrClFO₄
Molecular Weight:441.681
Hs Code.:

Synonyms:(2E,4Z)-1-(3-bromo-2-hydroxy-4,6-dimethoxyphenyl)-5-chloro-5-(4-fluoro phenyl)penta-2,4-dien-1-one

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Chemical Property of (2E,4Z)-1-(3-bromo-2-hydroxy-4,6-dimethoxyphenyl)-5-chloro-5-(4-fluoro phenyl)penta-2,4-dien-1-one

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Technology Process of (2E,4Z)-1-(3-bromo-2-hydroxy-4,6-dimethoxyphenyl)-5-chloro-5-(4-fluoro phenyl)penta-2,4-dien-1-one

There total 4 articles about (2E,4Z)-1-(3-bromo-2-hydroxy-4,6-dimethoxyphenyl)-5-chloro-5-(4-fluoro phenyl)penta-2,4-dien-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 18064-89-6
1-(3-bromo-2-hydroxyl-4,6-dimethoxyphenyl)ethanone

: 161891-29-8
(Z)-3-chloro-3-(4-fluorophenyl)acrylaldehyde

: 1374843-22-7
(2E,4Z)-1-(3-bromo-2-hydroxy-4,6-dimethoxyphenyl)-5-chloro-5-(4-fluoro phenyl)penta-2,4-dien-1-one

Guidance literature:: With sodium hydroxide; In ethanol; water; for 0.0833333h;
DOI:10.2174/157018011796576051

Reference yield:

: 90-24-4
2-hydroxy-4,6-dimethoxyacetophenone

: 1374843-22-7
(2E,4Z)-1-(3-bromo-2-hydroxy-4,6-dimethoxyphenyl)-5-chloro-5-(4-fluoro phenyl)penta-2,4-dien-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: bromine; acetic acid / 1 h / 20 °C

2: sodium hydroxide / ethanol; water / 0.08 h

With bromine; acetic acid; sodium hydroxide; In ethanol; water; 2: Claisen Schmidt condensation;
DOI:10.2174/157018011796576051

Reference yield:

: 621-23-8
1,2,3-trimethoxybenzene

: 1374843-22-7
(2E,4Z)-1-(3-bromo-2-hydroxy-4,6-dimethoxyphenyl)-5-chloro-5-(4-fluoro phenyl)penta-2,4-dien-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: aluminum (III) chloride / diethyl ether

2: bromine; acetic acid / 1 h / 20 °C

3: sodium hydroxide / ethanol; water / 0.08 h

With aluminum (III) chloride; bromine; acetic acid; sodium hydroxide; In diethyl ether; ethanol; water; 3: Claisen Schmidt condensation;
DOI:10.2174/157018011796576051