Ethyl 1-[2-(4-formylphenoxy)ethyl]-1H-indole-2-carboxylate

Base Information

Chemical Name:Ethyl 1-[2-(4-formylphenoxy)ethyl]-1H-indole-2-carboxylate
CAS No.:205371-44-4
Molecular Formula:C₂₀H₁₉NO₄
Molecular Weight:337.375
Hs Code.:
DSSTox Substance ID:DTXSID901192639

Synonyms:DTXSID901192639;Ethyl 1-[2-(4-formylphenoxy)ethyl]-1H-indole-2-carboxylate;205371-44-4

Suppliers and Price of Ethyl 1-[2-(4-formylphenoxy)ethyl]-1H-indole-2-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Ethyl 1-[2-(4-formylphenoxy)ethyl]-1H-indole-2-carboxylate

Chemical Property:

XLogP3:3.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:337.13140809
Heavy Atom Count:25
Complexity:447

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C1=CC2=CC=CC=C2N1CCOC3=CC=C(C=C3)C=O

Technology Process of Ethyl 1-[2-(4-formylphenoxy)ethyl]-1H-indole-2-carboxylate

There total 1 articles about Ethyl 1-[2-(4-formylphenoxy)ethyl]-1H-indole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3770-50-1,117770-52-2
2-carbethoxyindole

: 52191-15-8
4-(2-bromoethyloxy)benzaldehyde

: 205371-44-4
1-[2-(4-Formyl-phenoxy)-ethyl]-1H-indole-2-carboxylic acid ethyl ester

Guidance literature:: With potassium carbonate; Yield given. Multistep reaction; 1.) DMF, 25 deg C, 2.) DMF;
DOI:10.1021/jm970444e

Reference yield: 82.0%

: 2295-31-0
thiazoline-2,4-dione

: 205371-44-4
1-[2-(4-Formyl-phenoxy)-ethyl]-1H-indole-2-carboxylic acid ethyl ester

: 1-(2-{4-[2,4-Dioxo-thiazolidin-(5Z)-ylidenemethyl]-phenoxy}-ethyl)-1H-indole-2-carboxylic acid ethyl ester

Guidance literature:: With piperidine; benzoic acid; In toluene; for 1h; Heating;
DOI:10.1021/jm970444e

Reference yield:

: 205371-44-4
1-[2-(4-Formyl-phenoxy)-ethyl]-1H-indole-2-carboxylic acid ethyl ester

: 1-(2-{4-[2,4-Dioxo-thiazolidin-(5Z)-ylidenemethyl]-phenoxy}-ethyl)-1H-indole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / benzoic acid, piperidine / toluene / 1 h / Heating

2: 84 percent / KOH / dioxane / 1 h / 25 °C

With piperidine; potassium hydroxide; benzoic acid; In 1,4-dioxane; toluene;
DOI:10.1021/jm970444e