(2R,3S)-(-)-1-p-methoxybenzyloxy-3-methyl-7-(tert-butyldiphenylsilyloxy)-4-heptyn-2-ol

Base Information

Chemical Name:(2R,3S)-(-)-1-p-methoxybenzyloxy-3-methyl-7-(tert-butyldiphenylsilyloxy)-4-heptyn-2-ol
CAS No.:1245634-64-3
Molecular Formula:C₃₂H₄₀O₄Si
Molecular Weight:516.753
Hs Code.:

Synonyms:(2R,3S)-(-)-1-p-methoxybenzyloxy-3-methyl-7-(tert-butyldiphenylsilyloxy)-4-heptyn-2-ol

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Chemical Property of (2R,3S)-(-)-1-p-methoxybenzyloxy-3-methyl-7-(tert-butyldiphenylsilyloxy)-4-heptyn-2-ol

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Technology Process of (2R,3S)-(-)-1-p-methoxybenzyloxy-3-methyl-7-(tert-butyldiphenylsilyloxy)-4-heptyn-2-ol

There total 1 articles about (2R,3S)-(-)-1-p-methoxybenzyloxy-3-methyl-7-(tert-butyldiphenylsilyloxy)-4-heptyn-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1245634-63-2
(2S,3S)-2,3-epoxybutyl p-methoxybenzyl ether

: 88158-68-3
4-(tert-butyldiphenylsilyloxy)-1-butyne

: 1245634-64-3
(2R,3S)-(-)-1-p-methoxybenzyloxy-3-methyl-7-(tert-butyldiphenylsilyloxy)-4-heptyn-2-ol

Guidance literature:: 4-(tert-butyldiphenylsilyloxy)-1-butyne; With n-butyllithium; In diethyl ether; pentane; at 0 ℃; for 0.416667h; Inert atmosphere;

With trimethylaluminum; In diethyl ether; toluene; pentane; at -40 ℃; for 1h; Inert atmosphere;

(2S,3S)-2,3-epoxybutyl p-methoxybenzyl ether; With boron trifluoride diethyl etherate; In diethyl ether; toluene; pentane; for 4h; Inert atmosphere;
DOI:10.1021/ol101776e

Reference yield: 86.0%

: 1245634-64-3
(2R,3S)-(-)-1-p-methoxybenzyloxy-3-methyl-7-(tert-butyldiphenylsilyloxy)-4-heptyn-2-ol

: 107-30-2
chloromethyl methyl ether

: 1245634-65-4
(5S,6R)-(-)-1-(tert-butyldiphenylsilyloxy)-5-methyl-6-methoxymethoxy-7-p-methoxybenzyloxy-3-heptyne

Guidance literature:: With tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/ol101776e