4-{4-[2-(2-hydroxy-ethyl)-imidazol-1-ylmethyl]-oxazol-2-yl}-phenol

Base Information

• Chemical Name: 4-{4-[2-(2-hydroxy-ethyl)-imidazol-1-ylmethyl]-oxazol-2-yl}-phenol
• CAS No.: 851392-29-5
• Molecular Formula: C₁₅H₁₅N₃O₃
• Molecular Weight: 285.302
• Mol file: 851392-29-5.mol

Synonyms:4-{4-[2-(2-hydroxy-ethyl)-imidazol-1-ylmethyl]-oxazol-2-yl}-phenol

Chemical Property of 4-{4-[2-(2-hydroxy-ethyl)-imidazol-1-ylmethyl]-oxazol-2-yl}-phenol

Chemical Property:

Purity/Quality:

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Technology Process of 4-{4-[2-(2-hydroxy-ethyl)-imidazol-1-ylmethyl]-oxazol-2-yl}-phenol

There total 1 articles about 4-{4-[2-(2-hydroxy-ethyl)-imidazol-1-ylmethyl]-oxazol-2-yl}-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-{1-[2-(4-benzyloxy-phenyl)-oxazol-4-ylmethyl]-1H-imidazol-2-yl}-ethanol (851392-28-4) → 4-{4-[2-(2-hydroxy-ethyl)-imidazol-1-ylmethyl]-oxazol-2-yl}-phenol (851392-29-5)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; at 20 ℃; for 2h; under 760.051 Torr;

Reference yield: 20.0%

4-chloromethyl-2-[2-(4-chloro-2-fluoro-phenyl)-vinyl]-oxazole (866026-36-0) + 4-{4-[2-(2-hydroxy-ethyl)-imidazol-1-ylmethyl]-oxazol-2-yl}-phenol (851392-29-5) → 2-{1-[2-(4-{2-[(E)-2-(4-chloro-2-fluoro-phenyl)-vinyl]-oxazol-4-ylmethoxy}-phenyl)-oxazol-4-ylmethyl]-1H-imidazol-2-yl}-ethanol

Guidance literature:

4-{4-[2-(2-hydroxy-ethyl)-imidazol-1-ylmethyl]-oxazol-2-yl}-phenol; With caesium carbonate; In butanone; at 60 ℃; for 0.5h;

4-chloromethyl-2-[2-(4-chloro-2-fluoro-phenyl)-vinyl]-oxazole; With potassium iodide; at 60 ℃;

upstream raw materials:

2-{1-[2-(4-benzyloxy-phenyl)-oxazol-4-ylmethyl]-1H-imidazol-2-yl}-ethanol