2-[(4-Hydroxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-one--hydrogen chloride (1/1)

Base Information

Chemical Name:2-[(4-Hydroxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-one--hydrogen chloride (1/1)
CAS No.:111897-02-0
Molecular Formula:C14H17 N O2 . Cl H
Molecular Weight:267.7512
Hs Code.:
DSSTox Substance ID:DTXSID90920602

Synonyms:111897-02-0;DTXSID90920602;AKOS024325342;SR-01000496155;SR-01000496155-1;2-[(4-Hydroxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-one--hydrogen chloride (1/1)

Suppliers and Price of 2-[(4-Hydroxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-one--hydrogen chloride (1/1)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-[(4-Hydroxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-one--hydrogen chloride (1/1)

Chemical Property:

Vapor Pressure:4.12E-07mmHg at 25°C
Boiling Point:404.2°Cat760mmHg
Flash Point:198.3°C
Density:g/cm³
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:267.1026065
Heavy Atom Count:18
Complexity:289

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN2CCC1C(=O)C2CC3=CC=C(C=C3)O.Cl

Technology Process of 2-[(4-Hydroxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-one--hydrogen chloride (1/1)

There total 4 articles about 2-[(4-Hydroxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-one--hydrogen chloride (1/1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 111896-95-8
2-(4-Benzyloxybenzyl)-3-oxoquinuclidine

: 111897-02-0
2-(4-Oxybenzyl)-3-oxoquinuclidine hydrochloride

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; at 20 ℃;
DOI:10.1007/BF00758757

Reference yield:

: 3731-38-2
3-Quinuclidinone

: 111897-02-0
2-(4-Oxybenzyl)-3-oxoquinuclidine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / NaOH / ethanol / 1.) reflux, 2.5 h, 2.) 20 deg, 16 h

2: H₂, HCl / Pd/C / methanol / 20 °C

3: 79 percent / H₂, HCl / Pd/C / methanol / 20 °C

With hydrogenchloride; sodium hydroxide; hydrogen; palladium on activated charcoal; In methanol; ethanol;
DOI:10.1007/BF00758757

Reference yield:

: 4397-53-9
p-benzyloxybenzaldehyde

: 111897-02-0
2-(4-Oxybenzyl)-3-oxoquinuclidine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / NaOH / ethanol / 1.) reflux, 2.5 h, 2.) 20 deg, 16 h

2: H₂, HCl / Pd/C / methanol / 20 °C

3: 79 percent / H₂, HCl / Pd/C / methanol / 20 °C

With hydrogenchloride; sodium hydroxide; hydrogen; palladium on activated charcoal; In methanol; ethanol;
DOI:10.1007/BF00758757