{3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-5-methyl-1H-pyrrolo[3,2-b]pyridin-1-yl}acetic acid

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Chemical Name:{3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-5-methyl-1H-pyrrolo[3,2-b]pyridin-1-yl}acetic acid
CAS No.:1420071-02-8
Molecular Formula:C₂₄H₂₄F₃N₃O₃
Molecular Weight:459.468
Hs Code.:

Synonyms:{3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-5-methyl-1H-pyrrolo[3,2-b]pyridin-1-yl}acetic acid

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Chemical Property of {3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-5-methyl-1H-pyrrolo[3,2-b]pyridin-1-yl}acetic acid

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Technology Process of {3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-5-methyl-1H-pyrrolo[3,2-b]pyridin-1-yl}acetic acid

There total 5 articles about {3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-5-methyl-1H-pyrrolo[3,2-b]pyridin-1-yl}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1420070-28-5
ethyl {3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-5-methyl-1H-pyrrolo[3,2-b]pyridin-1-yl}acetate

: 1420071-02-8
{3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-5-methyl-1H-pyrrolo[3,2-b]pyridin-1-yl}acetic acid

Guidance literature:: With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield:

: 102684-91-3
2-bromo-5-(trifluoromethyl)benzaldehyde

: 1420071-02-8
{3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-5-methyl-1H-pyrrolo[3,2-b]pyridin-1-yl}acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium cyanoborohydride; acetic acid / methanol; tetrahydrofuran / 20 °C

2.1: triethylamine / dichloromethane / 20 °C

3.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 3 h / 100 °C / Schlenk technique; Sealed tube; Inert atmosphere

4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / 1,4-dioxane; water / 100 °C / Sealed tube; Inert atmosphere; Schlenk technique

5.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 1 h / 20 °C

5.2: pH 5

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; lithium hydroxide monohydrate; water; potassium acetate; sodium cyanoborohydride; caesium carbonate; acetic acid; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water;

Reference yield:

: 1175526-32-5
N-[2-bromo-5-(trifluoromethyl)benzyl]ethanamine

: 1420071-02-8
{3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-5-methyl-1H-pyrrolo[3,2-b]pyridin-1-yl}acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 20 °C

2.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 3 h / 100 °C / Schlenk technique; Sealed tube; Inert atmosphere

3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / 1,4-dioxane; water / 100 °C / Sealed tube; Inert atmosphere; Schlenk technique

4.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 1 h / 20 °C

4.2: pH 5

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; lithium hydroxide monohydrate; water; potassium acetate; caesium carbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;