3-(4-CYCLOPROPANECARBONYL-PHENYL)-ACRYLIC ACID METHYL ESTER

Base Information

• Chemical Name: 3-(4-CYCLOPROPANECARBONYL-PHENYL)-ACRYLIC ACID METHYL ESTER
• CAS No.: 575469-33-9
• Molecular Formula: C₁₄H₁₄O₃
• Molecular Weight: 230.263
• Mol file: 575469-33-9.mol

Synonyms:(E)-3-(4-(cyclopropylcarbonyl)phenyl)acrylic acid methyl ester

Chemical Property of 3-(4-CYCLOPROPANECARBONYL-PHENYL)-ACRYLIC ACID METHYL ESTER

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

METHYL-3-[4-(CYCLOPROPYLCARBONYL)PHENYL]ACRYLATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-CYCLOPROPANECARBONYL-PHENYL)-ACRYLIC ACID METHYL ESTER

There total 1 articles about 3-(4-CYCLOPROPANECARBONYL-PHENYL)-ACRYLIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4-bromophenyl)(cyclopropyl)methanone (6952-89-2) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → (E)-3-(4-(cyclopropylcarbonyl)phenyl)acrylic acid methyl ester (575469-33-9)

Guidance literature:

With triethylamine; triphenylphosphine; palladium diacetate; at 100 ℃; for 48h;

DOI:10.1016/j.bmc.2004.03.021

Reference yield:

(E)-3-(4-(cyclopropylcarbonyl)phenyl)acrylic acid methyl ester (575469-33-9) → (E)-3-(4-(cyclopropylcarbonyl)phenyl)acrylic acid (575469-35-1)

Guidance literature:

With lithium hydroxide; In 1,4-dioxane; water; at 20 ℃; for 16h;

DOI:10.1016/j.bmc.2004.03.021

Reference yield:

(E)-3-(4-(cyclopropylcarbonyl)phenyl)acrylic acid methyl ester (575469-33-9) → (E)-3-(4-Cyclopropanecarbonyl-phenyl)-1-((S)-2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-propenone

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium hydroxide / H₂O; dioxane / 16 h / 20 °C

2.1: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 3-hydroxy-1,2,3-benzotriazin-4(3H)-one / dimethylformamide; CH₂Cl₂ / 0 °C

2.2: triethylamine / dimethylformamide; CH₂Cl₂ / 0 - 20 °C

With lithium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2004.03.021

upstream raw materials:

(4-bromophenyl)(cyclopropyl)methanone

acrylic acid methyl ester

Downstream raw materials:

(E)-3-(4-(cyclopropylcarbonyl)phenyl)acrylic acid