5,11,17,23-Tetrakis<(benzyloxy)methyl>-25,26,27,28-tetrahydroxycalix<4>arene

Base Information

• Chemical Name: 5,11,17,23-Tetrakis<(benzyloxy)methyl>-25,26,27,28-tetrahydroxycalix<4>arene
• CAS No.: 157162-88-4
• Molecular Formula: C₆₀H₅₆O₈
• Molecular Weight: 905.1
• Mol file: 157162-88-4.mol

Synonyms:5,11,17,23-Tetrakis<(benzyloxy)methyl>-25,26,27,28-tetrahydroxycalix<4>arene

Chemical Property of 5,11,17,23-Tetrakis<(benzyloxy)methyl>-25,26,27,28-tetrahydroxycalix<4>arene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5,11,17,23-Tetrakis<(benzyloxy)methyl>-25,26,27,28-tetrahydroxycalix<4>arene

There total 4 articles about 5,11,17,23-Tetrakis<(benzyloxy)methyl>-25,26,27,28-tetrahydroxycalix<4>arene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

[25,26,27,28-tetrahydroxypentacyclo[19.3.1.1(3,7).1(9,13).1(15,19)]octacosa-1(25),3(28),4,6,9(27),10,12,15(26),16,18,21,23-dodecaene-5,11,17,23-tetrayl]tetrakis(N,N,N-trimethylmethanaminium) tetraiodide + benzyl alcohol (100-51-6,185532-71-2) → 5,11,17,23-Tetrakis<(benzyloxy)methyl>-25,26,27,28-tetrahydroxycalix<4>arene (157162-88-4)

Guidance literature:

With sodium hydride; In tetrahydrofuran; for 6h; Heating;

DOI:10.1021/jo00092a041

Reference yield: 56.0%

5,11,17,23-tetrakis(chloromethyl)pentacyclo[19.3.1.1(3,7).1(9,13).1(15,19)]octacosa-1(25),3(28),4,6,9(27),10,12,15(26),16,18,21,23-dodecaene-25,26,27,28-tetrol (124006-37-7,140146-43-6) + benzyl alcohol (100-51-6,185532-71-2) → 5,11,17,23-Tetrakis<(benzyloxy)methyl>-25,26,27,28-tetrahydroxycalix<4>arene (157162-88-4)

Guidance literature:

With sodium; In tetrahydrofuran; Inert atmosphere;

DOI:10.1039/b719482j

Reference yield:

25,26,27,28-tetrakis(hydroxy)calix[4]arene (248590-47-8,74568-07-3) → 5,11,17,23-Tetrakis<(benzyloxy)methyl>-25,26,27,28-tetrahydroxycalix<4>arene (157162-88-4)

Guidance literature:

Multi-step reaction with 3 steps

1: HOAc / tetrahydrofuran

2: 88 percent / dimethylsulfoxide / 3 h / Ambient temperature

3: 59 percent / NaH / tetrahydrofuran / 6 h / Heating

With sodium hydride; acetic acid; In tetrahydrofuran; dimethyl sulfoxide;

DOI:10.1021/jo00092a041

upstream raw materials:

benzyl alcohol

25,26,27,28-tetrakis(hydroxy)calix[4]arene

5,11,17,23-tetrakis[(dimethylamino)methyl]pentacyclo[19.3.1.1(3,7).1(9,13).1(15,19)]octacosa-1⁽²⁵⁾,3⁽²⁸⁾,4,6,9⁽²⁷⁾,10,12,15⁽²⁶⁾,16,18,21,23-dodecaene-25,26,27,28-tetrol

5,11,17,23-tetrakis(chloromethyl)pentacyclo[19.3.1.1(3,7).1(9,13).1(15,19)]octacosa-1⁽²⁵⁾,3⁽²⁸⁾,4,6,9⁽²⁷⁾,10,12,15⁽²⁶⁾,16,18,21,23-dodecaene-25,26,27,28-tetrol

Downstream raw materials:

1,3-alternate 5,11,17,23-tetrabenzyloxymethyl-25,26,27,28-tetrakis(ethoxycarbonylmethoxy)calix[4]arene