tert-butyl (R,R)-3-[N-benzyl-N-(α-methylbenzyl)amino]-4-(2',4',5'-trifluorophenyl)butanoate

Base Information

Chemical Name:tert-butyl (R,R)-3-[N-benzyl-N-(α-methylbenzyl)amino]-4-(2',4',5'-trifluorophenyl)butanoate
CAS No.:1380521-85-6
Molecular Formula:C₂₉H₃₂F₃NO₂
Molecular Weight:483.574
Hs Code.:

Synonyms:tert-butyl (R,R)-3-[N-benzyl-N-(α-methylbenzyl)amino]-4-(2',4',5'-trifluorophenyl)butanoate

Suppliers and Price of tert-butyl (R,R)-3-[N-benzyl-N-(α-methylbenzyl)amino]-4-(2',4',5'-trifluorophenyl)butanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl (R,R)-3-[N-benzyl-N-(α-methylbenzyl)amino]-4-(2',4',5'-trifluorophenyl)butanoate

Chemical Property:

Purity/Quality:: 98% HPLC ^*data from raw suppliers

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Technology Process of tert-butyl (R,R)-3-[N-benzyl-N-(α-methylbenzyl)amino]-4-(2',4',5'-trifluorophenyl)butanoate

There total 2 articles about tert-butyl (R,R)-3-[N-benzyl-N-(α-methylbenzyl)amino]-4-(2',4',5'-trifluorophenyl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1380521-84-5
tert-butyl (E)-4-(2',4',5'-trifluorophenyl)but-2-enoate

: 38235-77-7
(R)-N-benzyl-1-phenylethylamine

: 1380521-85-6
tert-butyl (R,R)-3-[N-benzyl-N-(α-methylbenzyl)amino]-4-(2',4',5'-trifluorophenyl)butanoate

Guidance literature:: (R)-N-benzyl-1-phenylethylamine; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.5h;

tert-butyl (E)-4-(2',4',5'-trifluorophenyl)but-2-enoate; In tetrahydrofuran; at -78 ℃; for 2h; optical yield given as %de; diastereoselective reaction;
DOI:10.1016/j.tetlet.2012.04.025

Reference yield:

: 27784-76-5
tert-butyl diethylphosphonoacetate

: 1380521-85-6
tert-butyl (R,R)-3-[N-benzyl-N-(α-methylbenzyl)amino]-4-(2',4',5'-trifluorophenyl)butanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: methylmagnesium bromide / tetrahydrofuran; diethyl ether / 0.25 h

1.2: 15 h / Reflux

2.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C

2.2: 2 h / -78 °C

With n-butyllithium; methylmagnesium bromide; In tetrahydrofuran; diethyl ether; 1.2: Wadsworth-Emmons reaction;
DOI:10.1016/j.tetlet.2012.04.025