4-methyl-1-(phenylmethyl) -N-amino>ethyl>amino>ethyl>amino>carbonyl>glycyl>-L-aspartate

Base Information

Chemical Name:4-methyl-1-(phenylmethyl) -N-amino>ethyl>amino>ethyl>amino>carbonyl>glycyl>-L-aspartate
CAS No.:144876-82-4
Molecular Formula:C₄₂H₄₄N₆O₉
Molecular Weight:776.846
Hs Code.:

4-methyl-1-(phenylmethyl) <R-(R*,R*)>-N-<N-<<<1-(1H-indol-3-ylmethyl)-2-oxo-2-<<2-phenyl-2-<<(phenylmethoxy)carbonyl>amino>ethyl>amino>ethyl>amino>carbonyl>glycyl>-L-aspartate

Synonyms:4-methyl-1-(phenylmethyl) -N-amino>ethyl>amino>ethyl>amino>carbonyl>glycyl>-L-aspartate

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Chemical Property of 4-methyl-1-(phenylmethyl) -N-amino>ethyl>amino>ethyl>amino>carbonyl>glycyl>-L-aspartate

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Technology Process of 4-methyl-1-(phenylmethyl) -N-amino>ethyl>amino>ethyl>amino>carbonyl>glycyl>-L-aspartate

There total 7 articles about 4-methyl-1-(phenylmethyl) -N-amino>ethyl>amino>ethyl>amino>carbonyl>glycyl>-L-aspartate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 51298-61-4
(S)-1-benzyl 4-methyl 2-aminosuccinate

: 144876-75-5
-6-(1H-indol-3-ylmethyl)-4,7,12-trioxo-10,14-diphenyl-13-oxa-3,5,8,11-tetraazadecanoic acid

: 144876-82-4
4-methyl-1-(phenylmethyl) -N-amino>ethyl>amino>ethyl>amino>carbonyl>glycyl>-L-aspartate

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 25 ℃; for 12h;
DOI:10.1016/S0040-4020(01)86596-0

Reference yield:

: 7362-93-8
(S)-3-amino-4-(benzyloxy)-4-oxobutanoic acid

: 144876-82-4
4-methyl-1-(phenylmethyl) -N-amino>ethyl>amino>ethyl>amino>carbonyl>glycyl>-L-aspartate

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / SOCl₂ / 17 h / Heating

2: 83 percent / BOP, i-Pr₂NEt / dimethylformamide / 12 h / 25 °C

With thionyl chloride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)86596-0

Reference yield:

: 130406-36-9,142854-51-1
((S)-2-Amino-1-phenyl-ethyl)-carbamic acid benzyl ester

: 144876-82-4
4-methyl-1-(phenylmethyl) -N-amino>ethyl>amino>ethyl>amino>carbonyl>glycyl>-L-aspartate

Guidance literature:: Multi-step reaction with 5 steps

1: 1) hydroxybenzotriazole hydrate, dicyclohexylcarbodiimide / 1) THF, EtOAc, 25 deg C, 2 h, 2) 25 deg C, 17 h

2: 89 percent / piperidine / dimethylformamide / 17 h / 0 °C

3: 83 percent / toluene; tetrahydrofuran / 16 h / 80 - 100 °C

4: 95 percent / LiOH*H₂O / tetrahydrofuran; H₂O / 25 °C

5: 83 percent / BOP, i-Pr₂NEt / dimethylformamide / 12 h / 25 °C

With piperidine; lithium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4020(01)86596-0