2-(morpholinylmethyl)-4-oxo-3,4,5,6,7,8-hexahydrobenzo(b)thieno(2,3-d)pyrimi

Base Information

• Chemical Name: 2-(morpholinylmethyl)-4-oxo-3,4,5,6,7,8-hexahydrobenzo(b)thieno(2,3-d)pyrimi
• CAS No.: 20887-01-8
• Molecular Formula: C₁₅H₁₉N₃O₂S
• Molecular Weight: 305.401
• Hs Code.: 2934999090

Synonyms:2-Morpholinomethyl-4-oxo-3,4,5,6,7,8-hexahydro-benzothieno<2-Morpholinomethyl-4-oxo-3,4,5,6,7,8-hexahydro-<1>benzothieno<2,3-d>pyrimidin;2-morpholinoethyl trimethylsilyl ether;

Chemical Property of 2-(morpholinylmethyl)-4-oxo-3,4,5,6,7,8-hexahydrobenzo(b)thieno(2,3-d)pyrimi

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 86.72000
• Density: 1.53g/cm³
• LogP: 2.04580

Purity/Quality:

97% ^*data from raw suppliers

2-(MORPHOLIN-4-YLMETHYL)-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONE 95.00% ^*data from reagent suppliers

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Technology Process of 2-(morpholinylmethyl)-4-oxo-3,4,5,6,7,8-hexahydrobenzo(b)thieno(2,3-d)pyrimi

There total 6 articles about 2-(morpholinylmethyl)-4-oxo-3,4,5,6,7,8-hexahydrobenzo(b)thieno(2,3-d)pyrimi which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

morpholine (110-91-8,99108-56-2) + 2-(chloromethyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one (89567-03-3) → 2-(morpholinomethyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one (20887-01-8)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 100 ℃; for 2h;

DOI:10.1021/acs.jmedchem.7b01565

Reference yield: 57.0%

4-morpholinoacetonitrile (5807-02-3) + ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (4506-71-2) → 2-(morpholinomethyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one (20887-01-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 18h;

DOI:10.2174/1570180814666171027161555

Reference yield:

2-(2-morpholin-4-yl-acetylamino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid amide (20887-00-7) → 2-(morpholinomethyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one (20887-01-8)

Guidance literature:

In glycerol; at 180 ℃;

DOI:10.1007/BF00904346

upstream raw materials:

2-(2-morpholin-4-yl-acetylamino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid amide

4-morpholinoacetonitrile

ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

morpholine

Downstream raw materials:

5-cyclohexyl-2-morpholin-4-ylmethyl-3H-pyrimidin-4-one

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