(S)-2-{(S)-1-[(S)-1-[(S)-1-((S)-1-Hydroxy-2-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-ethyl)-3-methyl-butylcarbamoyl]-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethoxymethyl}-pyrrolidine-1-carboxylic acid tert-butyl ester

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Chemical Name:(S)-2-{(S)-1-[(S)-1-[(S)-1-((S)-1-Hydroxy-2-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-ethyl)-3-methyl-butylcarbamoyl]-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethoxymethyl}-pyrrolidine-1-carboxylic acid tert-butyl ester
CAS No.:103352-64-3
Molecular Formula:C₄₅H₆₆N₈O₈
Molecular Weight:847.068
Hs Code.:

(S)-2-{(S)-1-[(S)-1-[(S)-1-((S)-1-Hydroxy-2-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-ethyl)-3-methyl-butylcarbamoyl]-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethoxymethyl}-pyrrolidine-1-carboxylic acid tert-butyl ester

Synonyms:(S)-2-{(S)-1-[(S)-1-[(S)-1-((S)-1-Hydroxy-2-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-ethyl)-3-methyl-butylcarbamoyl]-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethoxymethyl}-pyrrolidine-1-carboxylic acid tert-butyl ester

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Chemical Property of (S)-2-{(S)-1-[(S)-1-[(S)-1-((S)-1-Hydroxy-2-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-ethyl)-3-methyl-butylcarbamoyl]-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethoxymethyl}-pyrrolidine-1-carboxylic acid tert-butyl ester

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Technology Process of (S)-2-{(S)-1-[(S)-1-[(S)-1-((S)-1-Hydroxy-2-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-ethyl)-3-methyl-butylcarbamoyl]-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethoxymethyl}-pyrrolidine-1-carboxylic acid tert-butyl ester

There total 5 articles about (S)-2-{(S)-1-[(S)-1-[(S)-1-((S)-1-Hydroxy-2-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-ethyl)-3-methyl-butylcarbamoyl]-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethoxymethyl}-pyrrolidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 112374-72-8
C₅₂H₇₂N₈O₁₀S

: 103352-64-3
(S)-2-{(S)-1-[(S)-1-[(S)-1-((S)-1-Hydroxy-2-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-ethyl)-3-methyl-butylcarbamoyl]-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethoxymethyl}-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With benzotriazol-1-ol; In tetrahydrofuran;
DOI:10.1021/jm00398a029

Reference yield:

: 103336-10-3
Boc-ProψPhe-OH

: 103352-64-3
(S)-2-{(S)-1-[(S)-1-[(S)-1-((S)-1-Hydroxy-2-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-ethyl)-3-methyl-butylcarbamoyl]-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethoxymethyl}-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) trifluoroacetic acid, 2.) DCC / 1.) CH₂Cl₂, 30 min, 2.) room temperature, 2 h

2: 82 percent / 1-HOBt / tetrahydrofuran

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran;
DOI:10.1021/jm00398a029

Reference yield:

: 103372-25-4
{(S)-1-[(S)-1-((S)-1-Hydroxy-2-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-ethyl)-3-methyl-butylcarbamoyl]-2-[1-(toluene-4-sulfonyl)-1H-imidazol-4-yl]-ethyl}-carbamic acid tert-butyl ester

: 103352-64-3
(S)-2-{(S)-1-[(S)-1-[(S)-1-((S)-1-Hydroxy-2-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-ethyl)-3-methyl-butylcarbamoyl]-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethoxymethyl}-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) trifluoroacetic acid, 2.) DCC / 1.) CH₂Cl₂, 30 min, 2.) room temperature, 2 h

2: 82 percent / 1-HOBt / tetrahydrofuran

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran;
DOI:10.1021/jm00398a029