N-(2-Boc-amino-3-methylbutyliden)-L-phenylalanin-N-oxid-methylester

Base Information

• Chemical Name: N-(2-Boc-amino-3-methylbutyliden)-L-phenylalanin-N-oxid-methylester
• CAS No.: 104739-62-0
• Molecular Formula: C₂₀H₃₀N₂O₅
• Molecular Weight: 378.469
• Mol file: 104739-62-0.mol

Synonyms:N-(2-Boc-amino-3-methylbutyliden)-L-phenylalanin-N-oxid-methylester

Chemical Property of N-(2-Boc-amino-3-methylbutyliden)-L-phenylalanin-N-oxid-methylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-Boc-amino-3-methylbutyliden)-L-phenylalanin-N-oxid-methylester

There total 4 articles about N-(2-Boc-amino-3-methylbutyliden)-L-phenylalanin-N-oxid-methylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(S)-1-Methoxycarbonyl-2-phenylethylhydroxylamine (53933-45-2) + (S)-N-tert-butoxycarbonylvalinal (79069-51-5) → N-(2-Boc-amino-3-methylbutyliden)-L-phenylalanin-N-oxid-methylester (104739-62-0)

Guidance literature:

With calcium chloride; In diethyl ether; for 12h; Ambient temperature;

Reference yield:

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride (7524-50-7) → N-(2-Boc-amino-3-methylbutyliden)-L-phenylalanin-N-oxid-methylester (104739-62-0)

Guidance literature:

Multi-step reaction with 4 steps

1: Na₂CO₃ / methanol

2: 85 percent MCPBA

3: hydroxylammonium chloride

4: 94 percent / CaCl₂ / diethyl ether / 12 h / Ambient temperature

With hydroxylamine hydrochloride; sodium carbonate; 3-chloro-benzenecarboperoxoic acid; calcium chloride; In methanol; diethyl ether;

Reference yield:

(S)-2-{[1-(4-Methoxy-phenyl)-meth-(Z)-ylidene]-amino}-3-phenyl-propionic acid methyl ester (93473-36-0,73995-60-5) → N-(2-Boc-amino-3-methylbutyliden)-L-phenylalanin-N-oxid-methylester (104739-62-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent MCPBA

2: hydroxylammonium chloride

3: 94 percent / CaCl₂ / diethyl ether / 12 h / Ambient temperature

With hydroxylamine hydrochloride; 3-chloro-benzenecarboperoxoic acid; calcium chloride; In diethyl ether;

upstream raw materials:

(S)-1-Methoxycarbonyl-2-phenylethylhydroxylamine

(S)-N-tert-butoxycarbonylvalinal

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

(S)-2-{[1-(4-Methoxy-phenyl)-meth-(Z)-ylidene]-amino}-3-phenyl-propionic acid methyl ester

Downstream raw materials:

N-<(2S)-2-(tert-Butyloxycarbonylamino)-3-methylbutyl>-N-hydroxy-L-phenylalanin-methylester