E-1-acetyl-9-<4-hydroxyphenylmethylene>-12a-methyl-8-oxo-5-1,2,3,3a,3b,4,8,9,10b,11,12,12a-dodecahydrocyclopenta<7,8>phenanthro<3,4-b>furan

Base Information

Chemical Name:E-1-acetyl-9-<4-hydroxyphenylmethylene>-12a-methyl-8-oxo-5-1,2,3,3a,3b,4,8,9,10b,11,12,12a-dodecahydrocyclopenta<7,8>phenanthro<3,4-b>furan
CAS No.:134329-82-1
Molecular Formula:C₃₀H₃₂O₄
Molecular Weight:456.582
Hs Code.:

E-1-acetyl-9-<4-hydroxyphenylmethylene>-12a-methyl-8-oxo-5<H>-1,2,3,3a,3b,4,8,9,10b,11,12,12a-dodecahydrocyclopenta<7,8>phenanthro<3,4-b>furan

Synonyms:E-1-acetyl-9-<4-hydroxyphenylmethylene>-12a-methyl-8-oxo-5-1,2,3,3a,3b,4,8,9,10b,11,12,12a-dodecahydrocyclopenta<7,8>phenanthro<3,4-b>furan

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Chemical Property of E-1-acetyl-9-<4-hydroxyphenylmethylene>-12a-methyl-8-oxo-5-1,2,3,3a,3b,4,8,9,10b,11,12,12a-dodecahydrocyclopenta<7,8>phenanthro<3,4-b>furan

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Technology Process of E-1-acetyl-9-<4-hydroxyphenylmethylene>-12a-methyl-8-oxo-5-1,2,3,3a,3b,4,8,9,10b,11,12,12a-dodecahydrocyclopenta<7,8>phenanthro<3,4-b>furan

There total 5 articles about E-1-acetyl-9-<4-hydroxyphenylmethylene>-12a-methyl-8-oxo-5-1,2,3,3a,3b,4,8,9,10b,11,12,12a-dodecahydrocyclopenta<7,8>phenanthro<3,4-b>furan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 134329-81-0
1-acetyl-12a-methyl-8-oxo-5-1,2,3,3a,3b,4,8,9,10b,11,12,12a-dodecahydrocyclopenta<7,8>phenanthro<3,4-b>furan

: 134329-82-1
E-1-acetyl-9-<4-hydroxyphenylmethylene>-12a-methyl-8-oxo-5-1,2,3,3a,3b,4,8,9,10b,11,12,12a-dodecahydrocyclopenta<7,8>phenanthro<3,4-b>furan

Guidance literature:: With piperidine; In tetrahydrofuran; at 80 ℃; for 7h;
DOI:10.1016/0039-128X(91)90081-6

Reference yield:

: 1162-54-5
pregna-1,4-diene-3,20-dione

: 134329-82-1
E-1-acetyl-9-<4-hydroxyphenylmethylene>-12a-methyl-8-oxo-5-1,2,3,3a,3b,4,8,9,10b,11,12,12a-dodecahydrocyclopenta<7,8>phenanthro<3,4-b>furan

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / boron trifluoride etherate / 6 h / 25 - 30 °C

2: 75 percent / 2percent methanolic KOH / 5 h / 25 °C

3: 90 percent / AlCl₃ / CH₂Cl₂ / 2 h / 25 - 30 °C

4: 80 percent / sodium acetate / methanol / 5 h / Heating

5: 90 percent / piperidine / tetrahydrofuran / 7 h / 80 °C

With piperidine; potassium hydroxide; aluminium trichloride; boron trifluoride diethyl etherate; sodium acetate; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/0039-128X(91)90081-6

Reference yield:

: 100457-44-1
1-hydroxy-4-methyl-19-norpregna-1,3,5⁽¹⁰⁾-trien-20-one

: 134329-82-1
E-1-acetyl-9-<4-hydroxyphenylmethylene>-12a-methyl-8-oxo-5-1,2,3,3a,3b,4,8,9,10b,11,12,12a-dodecahydrocyclopenta<7,8>phenanthro<3,4-b>furan

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / AlCl₃ / CH₂Cl₂ / 2 h / 25 - 30 °C

2: 80 percent / sodium acetate / methanol / 5 h / Heating

3: 90 percent / piperidine / tetrahydrofuran / 7 h / 80 °C

With piperidine; aluminium trichloride; sodium acetate; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/0039-128X(91)90081-6