3-(4-bromo-2-nitrophenyl)-2-[2-(tert-butyldimethylsilanyloxy)ethyl]-N-(2,4-dichloro-6-iodophenyl)-N-methoxymethacrylamide

Base Information

Chemical Name:3-(4-bromo-2-nitrophenyl)-2-[2-(tert-butyldimethylsilanyloxy)ethyl]-N-(2,4-dichloro-6-iodophenyl)-N-methoxymethacrylamide
CAS No.:1027600-54-9
Molecular Formula:C₂₅H₃₀BrCl₂IN₂O₅Si
Molecular Weight:744.324
Hs Code.:

Synonyms:3-(4-bromo-2-nitrophenyl)-2-[2-(tert-butyldimethylsilanyloxy)ethyl]-N-(2,4-dichloro-6-iodophenyl)-N-methoxymethacrylamide

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Chemical Property of 3-(4-bromo-2-nitrophenyl)-2-[2-(tert-butyldimethylsilanyloxy)ethyl]-N-(2,4-dichloro-6-iodophenyl)-N-methoxymethacrylamide

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Technology Process of 3-(4-bromo-2-nitrophenyl)-2-[2-(tert-butyldimethylsilanyloxy)ethyl]-N-(2,4-dichloro-6-iodophenyl)-N-methoxymethacrylamide

There total 5 articles about 3-(4-bromo-2-nitrophenyl)-2-[2-(tert-butyldimethylsilanyloxy)ethyl]-N-(2,4-dichloro-6-iodophenyl)-N-methoxymethacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 3-(4-bromo-2-nitro-phenyl)-2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-N-(2,4-dichloro-6-iodo-phenyl)-acrylamide

: 107-30-2
chloromethyl methyl ether

: 1027600-54-9
3-(4-bromo-2-nitrophenyl)-2-[2-(tert-butyldimethylsilanyloxy)ethyl]-N-(2,4-dichloro-6-iodophenyl)-N-methoxymethacrylamide

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1021/jo061660a

Reference yield:

: 3-[1-(4-Bromo-2-nitro-phenyl)-meth-(E)-ylidene]-dihydro-furan-2-one

: 1027600-54-9
3-(4-bromo-2-nitrophenyl)-2-[2-(tert-butyldimethylsilanyloxy)ethyl]-N-(2,4-dichloro-6-iodophenyl)-N-methoxymethacrylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: AlMe₃ / benzene / 0.75 h

1.2: 81 percent / benzene; CH₂Cl₂ / 15 h / 65 °C

2.1: imidazole / dimethylformamide / 1 h / 20 °C

3.1: 84 percent / NaH / tetrahydrofuran / 0 - 20 °C

With 1H-imidazole; trimethylaluminum; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jo061660a

Reference yield:

: 2-[1-(4-Bromo-2-nitro-phenyl)-meth-(E)-ylidene]-N-(2,4-dichloro-6-iodo-phenyl)-4-hydroxy-butyramide

: 1027600-54-9
3-(4-bromo-2-nitrophenyl)-2-[2-(tert-butyldimethylsilanyloxy)ethyl]-N-(2,4-dichloro-6-iodophenyl)-N-methoxymethacrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: imidazole / dimethylformamide / 1 h / 20 °C

2: 84 percent / NaH / tetrahydrofuran / 0 - 20 °C

With 1H-imidazole; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jo061660a