ANTIBIOTIC MYC-8003

Base Information

• Chemical Name: ANTIBIOTIC MYC-8003
• CAS No.: 50935-71-2
• Molecular Formula: C43H60N2O12
• Molecular Weight: 796.956
• Mol file: 50935-71-2.mol

Synonyms:(2R)-N-[(2E,4E,6R)-7-[(2S,5R)-3,4-dihydroxy-5-[(1E,3E,5E)-7-(2-hydroxy-4-oxo-1H-pyridin-3-yl)-6-methyl-7-oxo-hepta-1,3,5-trienyl]oxolan-2-yl]-6-methoxy-5-methyl-octa-2,4-dienyl]-2-[2,3,4-trihydroxy-5,5-dimethyl-6-[(1E,3Z)-penta-1,3-dienyl]oxan-2-yl]butanamide;2H-Pyran-2-acetamide,N-[7-[(2E,4E,6S,7R)- 5-[(1E,2E,5E)-7-(1,2-dihydro-4-hydroxy-2- oxo-3-pyridinyl)-6-methyl-7-oxo-1,3,5- heptatrienyl]tetrahydro-3,4-dihydroxy-2- furanyl]-6-methoxy-5-methyl-2,4- octadienyl]-R-ethyltetrahydro-2,3,4- trihydroxy-5,5-dimethyl-6-[(1E,3E)-1,3- pentadienyl]-,(RS,2R,3R,4R,6S)-;2H-Pyran-2-acetamide, N-[7-[5-[7-(1, 2-dihydro-4-hydroxy-2-oxo-3-pyridinyl)-6-methyl-7-oxo-1,3, 5-heptatrienyl]tetrahydro-3, 4-dihydroxy-2-furanyl]-6-methoxy-5-methyl-2, 4-octadienyl]-.alpha.-ethyltetrahydro-2,3,4-trihydroxy-5, 5-dimethyl-6-(1,3-pentadienyl)-;MOCIMYCIN;(2S)-N-[(2E,4E,6S,7R)-7-[(2S,3R,4S,5R)-3,4-dihydroxy-5-[(1E,3E,5E)-7-(2-hydroxy-4-oxo-1H-pyridin-3-yl)-6-methyl-7-oxo-hepta-1,3,5-trienyl]oxolan-2-yl]-6-methoxy-5-methyl-octa-2,4-dienyl]-2-[(2R,3R,4R,6S)-2,3,4-trihydroxy-5,5-dimethyl-6-[(1E,3E)-penta-1,3-dienyl]oxan-2-yl]butanamide;Kirromycin;Delvomycin;

Chemical Property of ANTIBIOTIC MYC-8003

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.621
• Boiling Point: 936°C at 760 mmHg
• Flash Point: 519.9°C
• PSA: 228.10000
• Density: 1.279g/cm³
• LogP: 3.46570
• Storage Temp.: −20°C
• Solubility.: methanol: soluble1.90-2.10mg/mL, clear, yellow

Purity/Quality:

99.3% ^*data from raw suppliers

Kirromycin ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38-66
• Safety Statements: 26-36

MSDS Files:

Total 1 MSDS from other Authors

Useful:

• Description: Kirromycin is an antibiotic originally isolated from Streptomyces and an inhibitor of protein biosynthesis. It inhibits isoleucine incorporation, polyphenylalanine synthesis, and growth of B. brevis. Kirromycin inhibits elongation factor Tu-dependent peptidyl transfer activity in E. coli.
• Uses: Kirromycin from Streptomyces collinus is an antibiotic inhibitor of protein synthesis.

Technology Process of ANTIBIOTIC MYC-8003

There total 1 articles about ANTIBIOTIC MYC-8003 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ kirromycin (50935-71-2)

Guidance literature:

Reference yield:

kirromycin (50935-71-2) → 3-methoxy-2,4-dimethyl-8-(N'-phenylureido)-4E,6E-octadienal

Guidance literature:

Multi-step reaction with 3 steps

1: 87 percent / dioxane / 22 h / 35 °C

2: 50 percent / triethylamine / dimethylformamide / 1 h / 0 - 20 °C

3: 760 mg / sodium metaperiodate; ammonium acetate / H₂O; dioxane; methanol

With ammonium acetate; sodium periodate; triethylamine; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; 1: amidic cleavage / 2: Addition / 3: Oxidation;

DOI:10.7164/antibiotics.49.1249

Reference yield:

kirromycin (50935-71-2) → 3-methoxy-2,4-dimethyl-8-N-phenylureido-4E,6E-octadienol

Guidance literature:

Multi-step reaction with 4 steps

1: 87 percent / dioxane / 22 h / 35 °C

2: 50 percent / triethylamine / dimethylformamide / 1 h / 0 - 20 °C

3: 760 mg / sodium metaperiodate; ammonium acetate / H₂O; dioxane; methanol

4: 73 percent / sodium borohydride / ethanol / 0.75 h / 0 °C

With ammonium acetate; sodium tetrahydroborate; sodium periodate; triethylamine; In 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; 1: amidic cleavage / 2: Addition / 3: Oxidation / 4: Reduction;

DOI:10.7164/antibiotics.49.1249

Refernces