1α,3β-bis(tert-butyldimethylsilyloxy)-9,10-secocholesta-5,7,10(19)-triene

Base Information

Chemical Name:1α,3β-bis(tert-butyldimethylsilyloxy)-9,10-secocholesta-5,7,10(19)-triene
CAS No.:108887-35-0
Molecular Formula:C₃₉H₇₂O₂Si₂
Molecular Weight:629.17
Hs Code.:

Synonyms:1α,3β-bis(tert-butyldimethylsilyloxy)-9,10-secocholesta-5,7,10(19)-triene

Suppliers and Price of 1α,3β-bis(tert-butyldimethylsilyloxy)-9,10-secocholesta-5,7,10(19)-triene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of 1α,3β-bis(tert-butyldimethylsilyloxy)-9,10-secocholesta-5,7,10(19)-triene

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of 1α,3β-bis(tert-butyldimethylsilyloxy)-9,10-secocholesta-5,7,10(19)-triene

There total 24 articles about 1α,3β-bis(tert-butyldimethylsilyloxy)-9,10-secocholesta-5,7,10(19)-triene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 66251-18-1
Grundmann's ketone

: 81522-68-1
[(2Z)-2-[(3S,5R)-3,5-bis(tert-butyldimethylsilanyloxy)-2-methylenecyclohexylidene]ethyl]diphenylphosphine oxide

: 108887-35-0
1α,3β-bis(tert-butyldimethylsilyloxy)-9,10-secocholesta-5,7,10(19)-triene

Guidance literature:: [(2Z)-2-[(3S,5R)-3,5-bis(tert-butyldimethylsilanyloxy)-2-methylenecyclohexylidene]ethyl]diphenylphosphine oxide; With n-butyllithium; In tetrahydrofuran; at -75 ℃; for 0.0833333h;

Grundmann's ketone; In tetrahydrofuran; at -75 - 20 ℃; for 2h;
DOI:10.1248/cpb.48.215

Reference yield:

: 104651-47-0
(S)-2-[(1R,3aR,4S,7aR)-octahydro-4-[(1,1-dimethylethyl)dimethylsilyloxy]-7a-methyl-1H-inden-1-yl]propanal

: 108887-35-0
1α,3β-bis(tert-butyldimethylsilyloxy)-9,10-secocholesta-5,7,10(19)-triene

Guidance literature:: Multi-step reaction with 8 steps

1.1: 96 percent / PPh₃ / CH₂Cl₂ / 0.05 h / 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 1.5 h / -78 - 20 °C

2.2: 100 percent / tetrahydrofuran; hexane / 0.33 h / -78 °C

3.1: pyridine / CH₂Cl₂ / 2 h / 20 °C

4.1: 98 percent / n-Bu₃SnH; 2,2-azabisisobutyronitrile / toluene / 3 h / Heating

5.1: 68 percent / 6N HCl / tetrahydrofuran / 7 h / Heating

6.1: 56 percent / PCC; Celite / CH₂Cl₂ / 1.5 h / 20 °C

7.1: 100 percent / H₂ / 5 percent Pd/C / ethyl acetate / 0.5 h / 20 °C

8.1: n-BuLi / tetrahydrofuran / 0.08 h / -75 °C

8.2: 46 percent / tetrahydrofuran / 2 h / -75 - 20 °C

With pyridine; hydrogenchloride; n-butyllithium; 2,2'-azobis(isobutyronitrile); Celite; hydrogen; tri-n-butyl-tin hydride; triphenylphosphine; pyridinium chlorochromate; palladium on activated charcoal; In tetrahydrofuran; hexane; dichloromethane; ethyl acetate; toluene;
DOI:10.1248/cpb.48.215

Reference yield:

: 263712-15-8
(8β)-De-A,B-22-cholestyne-8-one

: 108887-35-0
1α,3β-bis(tert-butyldimethylsilyloxy)-9,10-secocholesta-5,7,10(19)-triene

Guidance literature:: Multi-step reaction with 2 steps

1.1: 100 percent / H₂ / 5 percent Pd/C / ethyl acetate / 0.5 h / 20 °C

2.1: n-BuLi / tetrahydrofuran / 0.08 h / -75 °C

2.2: 46 percent / tetrahydrofuran / 2 h / -75 - 20 °C

With n-butyllithium; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate;
DOI:10.1248/cpb.48.215