methyl 4-amino-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl)-picolinate

Base Information

Chemical Name:methyl 4-amino-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl)-picolinate
CAS No.:1391033-50-3
Molecular Formula:C₁₄H₁₁ClF₂N₂O₃
Molecular Weight:328.703
Hs Code.:

Synonyms:methyl 4-amino-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl)-picolinate

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Chemical Property of methyl 4-amino-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl)-picolinate

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Technology Process of methyl 4-amino-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl)-picolinate

There total 8 articles about methyl 4-amino-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl)-picolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1,3-propanediyl 4-chloro-2-fluoro-3-methoxyphenylboronate

: 1391055-90-5
methyl 4-amino-6-bromo-5-fluoropicolinate

: 1391033-50-3
methyl 4-amino-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl)-picolinate

Guidance literature:: With potassium fluoride; bis-triphenylphosphine-palladium(II) chloride; In water; acetonitrile; for 2h; Inert atmosphere; Reflux;

Reference yield:

: 496849-98-0
4,5,6-trichloro-2-pyridinecarbonitrile

: 1391033-50-3
methyl 4-amino-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl)-picolinate

Guidance literature:: Multi-step reaction with 4 steps

1.1: cesium fluoride / dimethyl sulfoxide / 24 h / 75 - 110 °C / Inert atmosphere

2.1: ammonium hydroxide / 2 h / 20 °C

3.1: hydrogen bromide / acetic acid / 3 h / 120 °C / Parr reaction vessel

3.2: 7 h / 110 °C / Parr reaction vessel

4.1: potassium fluoride / bis-triphenylphosphine-palladium(II) chloride / acetonitrile; water / 2 h / Inert atmosphere; Reflux

With potassium fluoride; ammonium hydroxide; hydrogen bromide; cesium fluoride; bis-triphenylphosphine-palladium(II) chloride; In water; acetic acid; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 1390662-56-2
benzyl 4,5,6-trichloropicolinate

: 1391033-50-3
methyl 4-amino-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl)-picolinate

Guidance literature:: Multi-step reaction with 4 steps

1: cesium fluoride / bis-triphenylphosphine-palladium(II) chloride / acetonitrile; water / 1.5 h / Inert atmosphere; Reflux

2: cesium fluoride / dimethyl sulfoxide / 6 h / 105 °C / Inert atmosphere

3: ammonia / dimethyl sulfoxide

4: methanol / 24 h

With ammonia; cesium fluoride; bis-triphenylphosphine-palladium(II) chloride; In methanol; water; dimethyl sulfoxide; acetonitrile;