4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)methoxy)piperidine

Base Information

Chemical Name:4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)methoxy)piperidine
CAS No.:1239964-60-3
Molecular Formula:C₂₄H₂₆Cl₂FN₃O
Molecular Weight:462.394
Hs Code.:

Synonyms:4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)methoxy)piperidine

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Chemical Property of 4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)methoxy)piperidine

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Technology Process of 4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)methoxy)piperidine

There total 13 articles about 4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)methoxy)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1239960-35-0
tert-butyl 4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)methoxy)piperidine-1-carboxylate

: 1239964-60-3
4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)methoxy)piperidine

Guidance literature:: tert-butyl 4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)methoxy)piperidine-1-carboxylate; With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃;

With sodium hydrogencarbonate; In dichloromethane;

Reference yield:

: 2-(3,4-dichlorophenyl)-2-methylpropanenitrile

: 1239964-60-3
4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)methoxy)piperidine

Guidance literature:: Multi-step reaction with 13 steps

1.1: diisobutylaluminium hydride / toluene / -78 °C

1.2: -78 - 20 °C

2.1: diethyl ether / 3 h / 0 - 20 °C

2.2: 0 °C

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.25 h / -78 °C

3.2: 1 h / -78 - 20 °C

4.1: tetra-N-butylammonium tribromide / methanol; dichloromethane / 24 h

5.1: hexamethylenetetramine / dichloromethane / 48 h / 20 °C

5.2: 2 h / Reflux

6.1: triethylamine / benzene / 6 h / Reflux

7.1: acetic acid / 5 h / Reflux

8.1: dihydrogen peroxide; acetic acid / dichloromethane / 0 - 20 °C

8.2: pH 9

9.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C

9.2: 3 h / -78 °C

10.1: sodium tetrahydroborate / ethanol / 3 h

11.1: thionyl chloride / acetonitrile / 3 h / 0 °C

12.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C

12.2: 20 °C

13.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

With sodium tetrahydroborate; n-butyllithium; thionyl chloride; oxalyl dichloride; hexamethylenetetramine; dihydrogen peroxide; tetra-N-butylammonium tribromide; sodium hydride; diisobutylaluminium hydride; acetic acid; dimethyl sulfoxide; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; dichloromethane; toluene; acetonitrile; mineral oil; benzene;

Reference yield:

: 3-(3,4-dichlorophenyl)-3-methylbutan-2-one

: 1239964-60-3
4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)methoxy)piperidine

Guidance literature:: Multi-step reaction with 10 steps

1.1: tetra-N-butylammonium tribromide / methanol; dichloromethane / 24 h

2.1: hexamethylenetetramine / dichloromethane / 48 h / 20 °C

2.2: 2 h / Reflux

3.1: triethylamine / benzene / 6 h / Reflux

4.1: acetic acid / 5 h / Reflux

5.1: dihydrogen peroxide; acetic acid / dichloromethane / 0 - 20 °C

5.2: pH 9

6.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C

6.2: 3 h / -78 °C

7.1: sodium tetrahydroborate / ethanol / 3 h

8.1: thionyl chloride / acetonitrile / 3 h / 0 °C

9.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C

9.2: 20 °C

10.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

With sodium tetrahydroborate; n-butyllithium; thionyl chloride; hexamethylenetetramine; dihydrogen peroxide; tetra-N-butylammonium tribromide; sodium hydride; acetic acid; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; acetonitrile; mineral oil; benzene;