(4R)-methyl 2-hydroxy-5-oxo-4-phenyl-3,4,5,6,7,8-hexahydro-2H-chromene-2-carboxylate

Base Information

Chemical Name:(4R)-methyl 2-hydroxy-5-oxo-4-phenyl-3,4,5,6,7,8-hexahydro-2H-chromene-2-carboxylate
CAS No.:1234199-84-8
Molecular Formula:C₁₇H₁₈O₅
Molecular Weight:302.327
Hs Code.:

Synonyms:(4R)-methyl 2-hydroxy-5-oxo-4-phenyl-3,4,5,6,7,8-hexahydro-2H-chromene-2-carboxylate

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Chemical Property of (4R)-methyl 2-hydroxy-5-oxo-4-phenyl-3,4,5,6,7,8-hexahydro-2H-chromene-2-carboxylate

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Technology Process of (4R)-methyl 2-hydroxy-5-oxo-4-phenyl-3,4,5,6,7,8-hexahydro-2H-chromene-2-carboxylate

There total 4 articles about (4R)-methyl 2-hydroxy-5-oxo-4-phenyl-3,4,5,6,7,8-hexahydro-2H-chromene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 107969-78-8,6395-86-4
methyl 4-phenyl-2-oxo-3-butenoate

: 504-02-9
1,3-cylohexanedione

: 1234199-84-8
(4R)-methyl 2-hydroxy-5-oxo-4-phenyl-3,4,5,6,7,8-hexahydro-2H-chromene-2-carboxylate

Guidance literature:: With C₃₆H₅₄N₄O₄; copper(II) bis(trifluoromethanesulfonate); In dichloromethane; at 20 ℃; for 12h; optical yield given as %ee; enantioselective reaction;
DOI:10.1002/chem.201002687

Reference yield: 98.0%

: 107969-78-8
methyl benzylidenepyruvate

: 30182-67-3
1,3-Cyclohexanedione

: 1234199-84-8
(4R)-methyl 2-hydroxy-5-oxo-4-phenyl-3,4,5,6,7,8-hexahydro-2H-chromene-2-carboxylate

Guidance literature:: With C₂₉H₂₉F₆N₃OS; In diethyl ether; at 20 ℃; for 5h; optical yield given as %ee; enantioselective reaction;
DOI:10.1002/adsc.201000045

Reference yield: 94.0%

: 504-02-9
1,3-cylohexanedione

: 103-26-4,1754-62-7
methyl cinnamate

: 1234199-84-8
(4R)-methyl 2-hydroxy-5-oxo-4-phenyl-3,4,5,6,7,8-hexahydro-2H-chromene-2-carboxylate

Guidance literature:: With C₄₅H₄₈O₃; diethylzinc; In tetrahydrofuran; hexane; at 10 ℃; for 24h; Concentration; Solvent; Reagent/catalyst; Time; Temperature; enantioselective reaction; Molecular sieve; Inert atmosphere;
DOI:10.1016/j.tet.2014.06.109