1-(3,5-dimethoxy-2-(5-methoxy-2,9-dimethylchromeno[2,3,4-ij]isoquinolin-11-yl)phenyl)propan-2-one

Base Information

Chemical Name:1-(3,5-dimethoxy-2-(5-methoxy-2,9-dimethylchromeno[2,3,4-ij]isoquinolin-11-yl)phenyl)propan-2-one
CAS No.:1314138-38-9
Molecular Formula:C₂₉H₂₇NO₅
Molecular Weight:469.537
Hs Code.:

Synonyms:1-(3,5-dimethoxy-2-(5-methoxy-2,9-dimethylchromeno[2,3,4-ij]isoquinolin-11-yl)phenyl)propan-2-one

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Chemical Property of 1-(3,5-dimethoxy-2-(5-methoxy-2,9-dimethylchromeno[2,3,4-ij]isoquinolin-11-yl)phenyl)propan-2-one

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Technology Process of 1-(3,5-dimethoxy-2-(5-methoxy-2,9-dimethylchromeno[2,3,4-ij]isoquinolin-11-yl)phenyl)propan-2-one

There total 26 articles about 1-(3,5-dimethoxy-2-(5-methoxy-2,9-dimethylchromeno[2,3,4-ij]isoquinolin-11-yl)phenyl)propan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1314138-32-3
C₃₃H₃₇NO₈

: 64-19-7,77671-22-8
acetic acid

: 1314138-38-9
1-(3,5-dimethoxy-2-(5-methoxy-2,9-dimethylchromeno[2,3,4-ij]isoquinolin-11-yl)phenyl)propan-2-one

: 1314138-39-0
1-(2-acetyl-3,5-dimethoxy-6-(5-methoxy-2,9-dimethylchromeno-[2,3,4-ij]isoquinolin-11-yl)phenyl)propan-2-one

Guidance literature:: With sulfuric acid; at 5 - 60 ℃; for 0.5h;
DOI:10.1021/ol201674a

Reference yield: 10.0%

: 1314138-32-3
C₃₃H₃₇NO₈

: 1314138-38-9
1-(3,5-dimethoxy-2-(5-methoxy-2,9-dimethylchromeno[2,3,4-ij]isoquinolin-11-yl)phenyl)propan-2-one

Guidance literature:: With sulfuric acid; In chloroform; at 60 ℃; for 1h;
DOI:10.1021/ol201674a

Reference yield:

: 1314138-40-3
C₁₃H₁₈O₄

: 1314138-38-9
1-(3,5-dimethoxy-2-(5-methoxy-2,9-dimethylchromeno[2,3,4-ij]isoquinolin-11-yl)phenyl)propan-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-Bromosuccinimide / chloroform / 3 h / 0 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.83 h / -78 °C / Inert atmosphere

2.2: 12 h / -78 - 20 °C / Inert atmosphere

3.1: hydrogenchloride / tetrahydrofuran; hexane; water

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 0.33 h / 20 °C / Inert atmosphere

4.2: 1 h / Inert atmosphere

4.3: 3 h / 80 °C / Inert atmosphere

5.1: caesium carbonate / dimethyl sulfoxide / 12 h / 90 °C

6.1: sulfuric acid / chloroform / 1 h / 60 °C

With hydrogenchloride; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; sulfuric acid; caesium carbonate; In tetrahydrofuran; 1,2-dimethoxyethane; hexane; chloroform; water; dimethyl sulfoxide; 4.1: Suzuki coupling / 4.2: Suzuki coupling / 4.3: Suzuki coupling / 6.1: Houben-Housch synthesis;
DOI:10.1021/ol201674a