Methyl 4-<3-(2-Amino-3,4-dihydro-4-oxo-5-deazapteridin-6-yl)propyl>benzoate

Base Information

Chemical Name:Methyl 4-<3-(2-Amino-3,4-dihydro-4-oxo-5-deazapteridin-6-yl)propyl>benzoate
CAS No.:123910-82-7
Molecular Formula:C₁₈H₁₈N₄O₃
Molecular Weight:338.366
Hs Code.:

Synonyms:Methyl 4-<3-(2-Amino-3,4-dihydro-4-oxo-5-deazapteridin-6-yl)propyl>benzoate

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Chemical Property of Methyl 4-<3-(2-Amino-3,4-dihydro-4-oxo-5-deazapteridin-6-yl)propyl>benzoate

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Technology Process of Methyl 4-<3-(2-Amino-3,4-dihydro-4-oxo-5-deazapteridin-6-yl)propyl>benzoate

There total 6 articles about Methyl 4-<3-(2-Amino-3,4-dihydro-4-oxo-5-deazapteridin-6-yl)propyl>benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 100643-27-4,143504-99-8
2,6-diamino-3H-pyrimidin-4-one

: 123910-85-0
Methyl 4-<6,6-dicyano-4-(ethoxymethylidene)-5-hexenyl>benzoate

: 123910-82-7
Methyl 4-<3-(2-Amino-3,4-dihydro-4-oxo-5-deazapteridin-6-yl)propyl>benzoate

Guidance literature:: In acetic acid; for 4h; Heating;
DOI:10.1021/jo00297a044

Reference yield:

: 619-42-1
4-methoxycarbonylphenyl bromide

: 123910-82-7
Methyl 4-<3-(2-Amino-3,4-dihydro-4-oxo-5-deazapteridin-6-yl)propyl>benzoate

Guidance literature:: Multi-step reaction with 6 steps

1: 83 percent / palladium chloride, triphenylphosphine, copper(I) iodide, diethylamine / 18 h / Ambient temperature

2: 100 percent / hydrogen / 5percent Pd/C / ethanol / 12 h / 2585.7 Torr

3: 60 percent / pyridinium chlorochromate, sodium acetate / CH₂Cl₂ / 12 h / Ambient temperature

4: 72 percent / DL-alanine / acetic acid; benzene / 3 h / Heating

5: 42 percent / acetic anhydride, zinc chloride / a) 145 deg C, 18 h b) 150 deg C, 12 h

6: 59 percent / aq. acetic acid / 4 h / Heating

With copper(l) iodide; hydrogen; sodium acetate; acetic anhydride; diethylamine; triphenylphosphine; rac-Ala-OH; pyridinium chlorochromate; palladium dichloride; zinc(II) chloride; palladium on activated charcoal; In ethanol; dichloromethane; acetic acid; benzene;
DOI:10.1021/jo00297a044

Reference yield:

: 123910-87-2
methyl 4-(5-hydroxypent-1-yn-1-yl)benzoate

: 123910-82-7
Methyl 4-<3-(2-Amino-3,4-dihydro-4-oxo-5-deazapteridin-6-yl)propyl>benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / hydrogen / 5percent Pd/C / ethanol / 12 h / 2585.7 Torr

2: 60 percent / pyridinium chlorochromate, sodium acetate / CH₂Cl₂ / 12 h / Ambient temperature

3: 72 percent / DL-alanine / acetic acid; benzene / 3 h / Heating

4: 42 percent / acetic anhydride, zinc chloride / a) 145 deg C, 18 h b) 150 deg C, 12 h

5: 59 percent / aq. acetic acid / 4 h / Heating

With hydrogen; sodium acetate; acetic anhydride; rac-Ala-OH; pyridinium chlorochromate; zinc(II) chloride; palladium on activated charcoal; In ethanol; dichloromethane; acetic acid; benzene;
DOI:10.1021/jo00297a044