N-[1-(4-{[(2R)-3-(acetylamino)-2-hydroxypropyl]amino}-2-fluorophenyl)-1H-1,2,4-triazol-3-yl]-2-phenylacetamide

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Chemical Name:N-[1-(4-{[(2R)-3-(acetylamino)-2-hydroxypropyl]amino}-2-fluorophenyl)-1H-1,2,4-triazol-3-yl]-2-phenylacetamide
CAS No.:266327-98-4
Molecular Formula:C₂₁H₂₃FN₆O₃
Molecular Weight:426.45
Hs Code.:

Synonyms:N-[1-(4-{[(2R)-3-(acetylamino)-2-hydroxypropyl]amino}-2-fluorophenyl)-1H-1,2,4-triazol-3-yl]-2-phenylacetamide

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Chemical Property of N-[1-(4-{[(2R)-3-(acetylamino)-2-hydroxypropyl]amino}-2-fluorophenyl)-1H-1,2,4-triazol-3-yl]-2-phenylacetamide

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Technology Process of N-[1-(4-{[(2R)-3-(acetylamino)-2-hydroxypropyl]amino}-2-fluorophenyl)-1H-1,2,4-triazol-3-yl]-2-phenylacetamide

There total 13 articles about N-[1-(4-{[(2R)-3-(acetylamino)-2-hydroxypropyl]amino}-2-fluorophenyl)-1H-1,2,4-triazol-3-yl]-2-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 266327-97-3
N-({(5S)-3-[4-({[(5-benzyl-1,2,4-oxadiazol-3-yl)imino]methyl}amino)-3-fluorophenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)acetamide

: 266327-98-4
N-[1-(4-{[(2R)-3-(acetylamino)-2-hydroxypropyl]amino}-2-fluorophenyl)-1H-1,2,4-triazol-3-yl]-2-phenylacetamide

Guidance literature:: With sodium hydroxide; In ethanol; at 20 ℃;
DOI:10.1021/jm990373e

Reference yield:

: 369-34-6
3,4-difluoronitrobenzene

: 266327-98-4
N-[1-(4-{[(2R)-3-(acetylamino)-2-hydroxypropyl]amino}-2-fluorophenyl)-1H-1,2,4-triazol-3-yl]-2-phenylacetamide

Guidance literature:: Multi-step reaction with 11 steps

1.1: 77 percent / N,N-diisopropylethylamine / acetonitrile / 6 h / 90 °C

2.1: H₂ / 5percent Pt/C / tetrahydrofuran / 6 h

3.1: N,N-dimethylaniline / tetrahydrofuran / 17 h / 20 °C

4.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 0.5 h / -78 °C

4.2: 77 percent / tetrahydrofuran / 24 h / -78 - 20 °C

5.1: NEt₃ / CH₂Cl₂ / 0.75 h / 0 °C

6.1: acetonitrile / 48 h / 95 °C

7.1: 99 percent / hydrazine monohydrate / methanol / 5 h / 80 °C

8.1: 89 percent / pyridine / 18 h / 0 - 20 °C

9.1: 77 percent / H₂ / 10percent Pd/C / ethanol / 23 h

10.1: 82 percent / ethanol; tetrahydrofuran / Heating

11.1: 89 percent / NaOH / ethanol / 20 °C

With pyridine; sodium hydroxide; hydrogen; hydrazine hydrate; N,N-dimethyl-aniline; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; 5percent Pt/C; 10percent Pd/C; In tetrahydrofuran; methanol; ethanol; dichloromethane; acetonitrile; 1.1: Substitution / 2.1: Reduction / 3.1: Acylation / 4.1: Metallation / 4.2: Ring cleavage / 5.1: mesylation / 6.1: Substitution / 7.1: hydrazinolysis / 8.1: Acetylation / 9.1: Hydrogenolysis / 10.1: Condensation / 11.1: Ring cleavage;
DOI:10.1021/jm990373e

Reference yield:

: 219664-14-9
N-(4-amino-2-fluorophenyl)-N-benzylamine

: 266327-98-4
N-[1-(4-{[(2R)-3-(acetylamino)-2-hydroxypropyl]amino}-2-fluorophenyl)-1H-1,2,4-triazol-3-yl]-2-phenylacetamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: N,N-dimethylaniline / tetrahydrofuran / 17 h / 20 °C

2.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 0.5 h / -78 °C

2.2: 77 percent / tetrahydrofuran / 24 h / -78 - 20 °C

3.1: NEt₃ / CH₂Cl₂ / 0.75 h / 0 °C

4.1: acetonitrile / 48 h / 95 °C

5.1: 99 percent / hydrazine monohydrate / methanol / 5 h / 80 °C

6.1: 89 percent / pyridine / 18 h / 0 - 20 °C

7.1: 77 percent / H₂ / 10percent Pd/C / ethanol / 23 h

8.1: 82 percent / ethanol; tetrahydrofuran / Heating

9.1: 89 percent / NaOH / ethanol / 20 °C

With pyridine; sodium hydroxide; hydrogen; hydrazine hydrate; N,N-dimethyl-aniline; triethylamine; lithium hexamethyldisilazane; 10percent Pd/C; In tetrahydrofuran; methanol; ethanol; dichloromethane; acetonitrile; 1.1: Acylation / 2.1: Metallation / 2.2: Ring cleavage / 3.1: mesylation / 4.1: Substitution / 5.1: hydrazinolysis / 6.1: Acetylation / 7.1: Hydrogenolysis / 8.1: Condensation / 9.1: Ring cleavage;
DOI:10.1021/jm990373e