(E)-1,2-dimethoxy-3-methyl-4-(4-methyl-1-(phenylsulfonyl)oct-3-en-7-yn-1-yl)benzene

Base Information

Chemical Name:(E)-1,2-dimethoxy-3-methyl-4-(4-methyl-1-(phenylsulfonyl)oct-3-en-7-yn-1-yl)benzene
CAS No.:1527482-80-9
Molecular Formula:C₂₄H₂₈O₄S
Molecular Weight:412.55
Hs Code.:

Synonyms:(E)-1,2-dimethoxy-3-methyl-4-(4-methyl-1-(phenylsulfonyl)oct-3-en-7-yn-1-yl)benzene

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Chemical Property of (E)-1,2-dimethoxy-3-methyl-4-(4-methyl-1-(phenylsulfonyl)oct-3-en-7-yn-1-yl)benzene

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Technology Process of (E)-1,2-dimethoxy-3-methyl-4-(4-methyl-1-(phenylsulfonyl)oct-3-en-7-yn-1-yl)benzene

There total 8 articles about (E)-1,2-dimethoxy-3-methyl-4-(4-methyl-1-(phenylsulfonyl)oct-3-en-7-yn-1-yl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: (E)-3-methylhept-2-en-6-yn-1-yl acetate

: 1527482-78-5
1,2-dimethoxy-3-methyl-4-(phenylsulfonylmethyl)benzene

: 1527482-80-9
(E)-1,2-dimethoxy-3-methyl-4-(4-methyl-1-(phenylsulfonyl)oct-3-en-7-yn-1-yl)benzene

Guidance literature:: 1,2-dimethoxy-3-methyl-4-(phenylsulfonylmethyl)benzene; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; Inert atmosphere;

(E)-3-methylhept-2-en-6-yn-1-yl acetate; In tetrahydrofuran; at 23 ℃; Further stages; Inert atmosphere;
DOI:10.1021/ja4125093

Reference yield:

: 37715-31-4
(E)-5-(3,3-dimethyloxiran-2-yl)-3-methylpent-2-enyl acetate

: 1527482-80-9
(E)-1,2-dimethoxy-3-methyl-4-(4-methyl-1-(phenylsulfonyl)oct-3-en-7-yn-1-yl)benzene

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium periodate; H⁽¹⁺⁾*IO₄^(1-)*2H₂O=HIO₄*2H₂O / tetrahydrofuran; water / 1 h / 0 °C / Inert atmosphere

2.1: potassium carbonate; methanol / water / 8 h / 23 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 0 °C / Inert atmosphere

4.1: lithium diisopropyl amide / tetrahydrofuran / -78 °C / Inert atmosphere

4.2: 23 °C / Inert atmosphere

With methanol; sodium periodate; H⁽¹⁺⁾*IO₄^(1-)*2H₂O=HIO₄*2H₂O; potassium carbonate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/ja4125093

Reference yield:

: 21831-10-7
1-(bromomethyl)-3,4-dimethoxy-2-methylbenzene

: 1527482-80-9
(E)-1,2-dimethoxy-3-methyl-4-(4-methyl-1-(phenylsulfonyl)oct-3-en-7-yn-1-yl)benzene

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N-dimethyl-formamide / 13 h / 0 - 23 °C / Inert atmosphere

2.1: lithium diisopropyl amide / tetrahydrofuran / -78 °C / Inert atmosphere

2.2: 23 °C / Inert atmosphere

With lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ja4125093