(1R,4R,5S)-(-)-1-<3-<(benzyloxy)methyl>-4,5-(isopropylidenedioxy)-2-cyclopentenyl>-4-thioxouracil

Base Information

Chemical Name:(1R,4R,5S)-(-)-1-<3-<(benzyloxy)methyl>-4,5-(isopropylidenedioxy)-2-cyclopentenyl>-4-thioxouracil
CAS No.:92642-70-1
Molecular Formula:C₂₀H₂₂N₂O₄S
Molecular Weight:386.472
Hs Code.:

Synonyms:(1R,4R,5S)-(-)-1-<3-<(benzyloxy)methyl>-4,5-(isopropylidenedioxy)-2-cyclopentenyl>-4-thioxouracil

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Chemical Property of (1R,4R,5S)-(-)-1-<3-<(benzyloxy)methyl>-4,5-(isopropylidenedioxy)-2-cyclopentenyl>-4-thioxouracil

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Technology Process of (1R,4R,5S)-(-)-1-<3-<(benzyloxy)methyl>-4,5-(isopropylidenedioxy)-2-cyclopentenyl>-4-thioxouracil

There total 8 articles about (1R,4R,5S)-(-)-1-<3-<(benzyloxy)methyl>-4,5-(isopropylidenedioxy)-2-cyclopentenyl>-4-thioxouracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 92642-69-8
(1R,4R,5S)-(-)-1-<3-<(benzyloxy)methyl>-4,5-(isopropylidenedioxy)-2-cyclopentenyl>uracil

: 92642-70-1
(1R,4R,5S)-(-)-1-<3-<(benzyloxy)methyl>-4,5-(isopropylidenedioxy)-2-cyclopentenyl>-4-thioxouracil

Guidance literature:: With Lawessons reagent; In benzene; for 0.75h; Heating;
DOI:10.1021/jm00378a002

Reference yield:

: 92642-68-7
(1R,4R,5S)-(-)-1-<3-<(benzyloxy)methyl>-4,5-(isopropylidenedioxy)-2-cyclopentenyl>-5-(ethoxycarbonyl)uracil

: 92642-70-1
(1R,4R,5S)-(-)-1-<3-<(benzyloxy)methyl>-4,5-(isopropylidenedioxy)-2-cyclopentenyl>-4-thioxouracil

Guidance literature:: Multi-step reaction with 3 steps

1: 71 percent / lithium hydroxide monohydrate / methanol / 2 h / Ambient temperature

2: 71 percent / cuprous oxide, 1,10-phenanthroline / quinoline / 0.25 h / 170 °C

3: 64 percent / Lawesson's reagent / hexamethylphosphoric acid triamide / 2.45 h / 100 °C

With Lawessons reagent; copper(I) oxide; lithium hydroxide; 1,10-Phenanthroline; In quinoline; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1021/jm00117a004

Reference yield:

: 115983-80-7
(1R,4R,5S)-(-)-1-<3-<(benzyloxy)methyl>-4,5-(isopropylidenedioxy)-2-cyclopentenyl>-5-uracilcarboxylic acid

: 92642-70-1
(1R,4R,5S)-(-)-1-<3-<(benzyloxy)methyl>-4,5-(isopropylidenedioxy)-2-cyclopentenyl>-4-thioxouracil

Guidance literature:: Multi-step reaction with 2 steps

1: 71 percent / cuprous oxide, 1,10-phenanthroline / quinoline / 0.25 h / 170 °C

2: 64 percent / Lawesson's reagent / hexamethylphosphoric acid triamide / 2.45 h / 100 °C

With Lawessons reagent; copper(I) oxide; 1,10-Phenanthroline; In quinoline; N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1021/jm00117a004