(2R,3S,4S)-5-(4-methoxybenzyloxy)-3-trimethylsiloxy-2,4-dimethylpentanal

Base Information

Chemical Name:(2R,3S,4S)-5-(4-methoxybenzyloxy)-3-trimethylsiloxy-2,4-dimethylpentanal
CAS No.:900170-92-5
Molecular Formula:C₁₈H₃₀O₄Si
Molecular Weight:338.519
Hs Code.:

Synonyms:(2R,3S,4S)-5-(4-methoxybenzyloxy)-3-trimethylsiloxy-2,4-dimethylpentanal

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Chemical Property of (2R,3S,4S)-5-(4-methoxybenzyloxy)-3-trimethylsiloxy-2,4-dimethylpentanal

Chemical Property:

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Technology Process of (2R,3S,4S)-5-(4-methoxybenzyloxy)-3-trimethylsiloxy-2,4-dimethylpentanal

There total 3 articles about (2R,3S,4S)-5-(4-methoxybenzyloxy)-3-trimethylsiloxy-2,4-dimethylpentanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 900170-88-9
(3R,4S)-4-<(S)-1-(4-methoxybenzyloxy)propan-2-yl>-3-methyloxetan-2-one

: 900170-92-5
(2R,3S,4S)-5-(4-methoxybenzyloxy)-3-trimethylsiloxy-2,4-dimethylpentanal

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / Me₂AlCl / CH₂Cl₂; hexane / 1 h / 20 °C

2: 86 percent / 2,6-lutidine / CH₂Cl₂ / -78 - 20 °C

3: 80 percent / t-Bu₂AlH / tetrahydrofuran / 3 h / -78 °C

With 2,6-dimethylpyridine; dimethylaluminum chloride; di(tert-butyl)aluminium hydride; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ja061938g

Reference yield:

: 132969-60-9
(2S)-3-[(4-methoxybenzyl)oxy]-2-methylpropanal

: 900170-92-5
(2R,3S,4S)-5-(4-methoxybenzyloxy)-3-trimethylsiloxy-2,4-dimethylpentanal

Guidance literature:: Multi-step reaction with 4 steps

1: 74 percent / LiClO₄; O-trimethylsilylquinine; N,N-diisopropylethylamine / CH₂Cl₂; diethyl ether / 16 h / -78 °C

2: 80 percent / Me₂AlCl / CH₂Cl₂; hexane / 1 h / 20 °C

3: 86 percent / 2,6-lutidine / CH₂Cl₂ / -78 - 20 °C

4: 80 percent / t-Bu₂AlH / tetrahydrofuran / 3 h / -78 °C

With 2,6-dimethylpyridine; (1S,2R,4S,5R)-2-[(S)-(6-methoxyquinolin-4-yl)((trimethylsilyl)oxy)methyl]-5-vinylquinuclidine; lithium perchlorate; dimethylaluminum chloride; di(tert-butyl)aluminium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; hexane; dichloromethane;
DOI:10.1021/ja061938g

Reference yield:

: 252342-49-7
(2R,3S,4S)-3-hydroxy-5-(4-methoxybenzyloxy)-2,4-dimethylpentanoic acid methoxymethylamide

: 900170-92-5
(2R,3S,4S)-5-(4-methoxybenzyloxy)-3-trimethylsiloxy-2,4-dimethylpentanal

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / 2,6-lutidine / CH₂Cl₂ / -78 - 20 °C

2: 80 percent / t-Bu₂AlH / tetrahydrofuran / 3 h / -78 °C

With 2,6-dimethylpyridine; di(tert-butyl)aluminium hydride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja061938g