(S)-3-[4-(4'-chloro-2'-methylbiphenyl-3-ylmethoxy)phenyl]-3-(1-methyl-1H-tetrazol-5-yl)propionic acid

Base Information

Chemical Name:(S)-3-[4-(4'-chloro-2'-methylbiphenyl-3-ylmethoxy)phenyl]-3-(1-methyl-1H-tetrazol-5-yl)propionic acid
CAS No.:916219-71-1
Molecular Formula:C₂₅H₂₃ClN₄O₃
Molecular Weight:462.936
Hs Code.:

Synonyms:(S)-3-[4-(4'-chloro-2'-methylbiphenyl-3-ylmethoxy)phenyl]-3-(1-methyl-1H-tetrazol-5-yl)propionic acid

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Chemical Property of (S)-3-[4-(4'-chloro-2'-methylbiphenyl-3-ylmethoxy)phenyl]-3-(1-methyl-1H-tetrazol-5-yl)propionic acid

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Technology Process of (S)-3-[4-(4'-chloro-2'-methylbiphenyl-3-ylmethoxy)phenyl]-3-(1-methyl-1H-tetrazol-5-yl)propionic acid

There total 8 articles about (S)-3-[4-(4'-chloro-2'-methylbiphenyl-3-ylmethoxy)phenyl]-3-(1-methyl-1H-tetrazol-5-yl)propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₆H₂₅ClN₄O₃

: 916219-71-1
(S)-3-[4-(4'-chloro-2'-methylbiphenyl-3-ylmethoxy)phenyl]-3-(1-methyl-1H-tetrazol-5-yl)propionic acid

Guidance literature:: C₂₆H₂₅ClN₄O₃; With methanol; sodium hydroxide; water; In tetrahydrofuran; for 8h;

With hydrogenchloride; In water; dimethyl sulfoxide; pH=2;

Reference yield:

: C₂₇H₂₅F₃O₃

: 916219-71-1
(S)-3-[4-(4'-chloro-2'-methylbiphenyl-3-ylmethoxy)phenyl]-3-(1-methyl-1H-tetrazol-5-yl)propionic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: 2,6-dimethylpyridine; osmium(VIII) oxide / water; tert-butyl alcohol / 0.08 h

1.2: 20 - 30 °C

2.1: potassium dihydrogenphosphate; dihydrogen peroxide; sodium chlorite / water; acetonitrile / 3 h / -5 - 0 °C

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran; dichloromethane / 8 h

4.1: sodium azide; trifluoromethylsulfonic anhydride / acetonitrile / 12 h / 34 °C / Inert atmosphere

5.1: hydrogen; 5%-palladium/activated carbon / water; ethyl acetate / 8 h

6.1: caesium carbonate / N,N-dimethyl-formamide / 14 h / Inert atmosphere

7.1: sodium hydroxide; water / tetrahydrofuran / 8 h / Inert atmosphere

With 2,6-dimethylpyridine; sodium chlorite; potassium dihydrogenphosphate; osmium(VIII) oxide; sodium azide; trifluoromethylsulfonic anhydride; 5%-palladium/activated carbon; water; hydrogen; dihydrogen peroxide; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;
DOI:10.1021/ml400501x

Reference yield:

: 865233-37-0
(3S)-3-[4-(4'-trifluoromethyl-biphenyl-3-ylmethoxy)-phenyl]-hex-4-ynoic acid methyl ester

: 916219-71-1
(S)-3-[4-(4'-chloro-2'-methylbiphenyl-3-ylmethoxy)phenyl]-3-(1-methyl-1H-tetrazol-5-yl)propionic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogen; quinoline / ethyl acetate / 8 h / Inert atmosphere

2.1: 2,6-dimethylpyridine; osmium(VIII) oxide / water; tert-butyl alcohol / 0.08 h

2.2: 20 - 30 °C

3.1: potassium dihydrogenphosphate; dihydrogen peroxide; sodium chlorite / water; acetonitrile / 3 h / -5 - 0 °C

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran; dichloromethane / 8 h

5.1: sodium azide; trifluoromethylsulfonic anhydride / acetonitrile / 12 h / 34 °C / Inert atmosphere

6.1: hydrogen; 5%-palladium/activated carbon / water; ethyl acetate / 8 h

7.1: caesium carbonate / N,N-dimethyl-formamide / 14 h / Inert atmosphere

8.1: sodium hydroxide; water / tetrahydrofuran / 8 h / Inert atmosphere

With 2,6-dimethylpyridine; quinoline; sodium chlorite; potassium dihydrogenphosphate; osmium(VIII) oxide; sodium azide; trifluoromethylsulfonic anhydride; 5%-palladium/activated carbon; water; hydrogen; dihydrogen peroxide; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;
DOI:10.1021/ml400501x