(2R,5S)-5-Dibenzylamino-4-oxo-6-phenyl-2-propyl-hexanoic acid methyl ester

Base Information

• Chemical Name: (2R,5S)-5-Dibenzylamino-4-oxo-6-phenyl-2-propyl-hexanoic acid methyl ester
• CAS No.: 194551-74-1
• Molecular Formula: C₃₀H₃₅NO₃
• Molecular Weight: 457.613
• Mol file: 194551-74-1.mol

Synonyms:(2R,5S)-5-Dibenzylamino-4-oxo-6-phenyl-2-propyl-hexanoic acid methyl ester

Chemical Property of (2R,5S)-5-Dibenzylamino-4-oxo-6-phenyl-2-propyl-hexanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,5S)-5-Dibenzylamino-4-oxo-6-phenyl-2-propyl-hexanoic acid methyl ester

There total 3 articles about (2R,5S)-5-Dibenzylamino-4-oxo-6-phenyl-2-propyl-hexanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-((S)-2-Dibenzylamino-3-phenyl-propionyl)-3-propyl-succinic acid 1-tert-butyl ester 4-methyl ester → (2R,5S)-5-Dibenzylamino-4-oxo-6-phenyl-2-propyl-hexanoic acid methyl ester (194551-74-1)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 24h; Yield given; Ambient temperature;

DOI:10.1021/jo970579s

Reference yield:

(R)-2-Trifluoromethanesulfonyloxy-pentanoic acid methyl ester (191731-20-1) → (2R,5S)-5-Dibenzylamino-4-oxo-6-phenyl-2-propyl-hexanoic acid methyl ester (194551-74-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH / 1) THF, 0 deg C, 10 min; 2) THF, CH₂Cl₂, rt, 24 h

2: TFA / CH₂Cl₂ / 24 h / Ambient temperature

With sodium hydride; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/jo970579s

Reference yield:

tert-butyl 4-(N,N-dibenzylamino)-3-oxo-5-phenylpentanoate (188774-99-4) → (2R,5S)-5-Dibenzylamino-4-oxo-6-phenyl-2-propyl-hexanoic acid methyl ester (194551-74-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH / 1) THF, 0 deg C, 10 min; 2) THF, CH₂Cl₂, rt, 24 h

2: TFA / CH₂Cl₂ / 24 h / Ambient temperature

With sodium hydride; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/jo970579s

upstream raw materials:

(R)-2-Trifluoromethanesulfonyloxy-pentanoic acid methyl ester

tert-butyl 4-(N,N-dibenzylamino)-3-oxo-5-phenylpentanoate

Downstream raw materials:

(2R,4S,5S)-5-Dibenzylamino-4-hydroxy-6-phenyl-2-propyl-hexanoic acid methyl ester