3-amino-1-(3-fluorophenyl)-5,10-dihydro-5,10-dioxo-1H-pyrazolo[1,2-b]phthalazine-2-carbonitrile

Base Information

Chemical Name:3-amino-1-(3-fluorophenyl)-5,10-dihydro-5,10-dioxo-1H-pyrazolo[1,2-b]phthalazine-2-carbonitrile
CAS No.:1443004-18-9
Molecular Formula:C₁₈H₁₁FN₄O₂
Molecular Weight:334.309
Hs Code.:

Synonyms:3-amino-1-(3-fluorophenyl)-5,10-dihydro-5,10-dioxo-1H-pyrazolo[1,2-b]phthalazine-2-carbonitrile

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Chemical Property of 3-amino-1-(3-fluorophenyl)-5,10-dihydro-5,10-dioxo-1H-pyrazolo[1,2-b]phthalazine-2-carbonitrile

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Technology Process of 3-amino-1-(3-fluorophenyl)-5,10-dihydro-5,10-dioxo-1H-pyrazolo[1,2-b]phthalazine-2-carbonitrile

There total 3 articles about 3-amino-1-(3-fluorophenyl)-5,10-dihydro-5,10-dioxo-1H-pyrazolo[1,2-b]phthalazine-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1445-69-8
2,3-dihydrophthalazine-1,4-dione

: 109-77-3
malononitrile

: 456-48-4
3-Fluorobenzaldehyde

: 1443004-18-9
3-amino-1-(3-fluorophenyl)-5,10-dihydro-5,10-dioxo-1H-pyrazolo[1,2-b]phthalazine-2-carbonitrile

Guidance literature:: With Caesium carbonate supported on hydroxyapatite-encapsulated Ni_0.5Zn_0.5Fe₂O₄ nanocrystallites; In neat (no solvent); at 110 ℃; for 0.166667h;
DOI:10.1002/aoc.3288

Reference yield: 92.0%

: 85-44-9
phthalic anhydride

: 109-77-3
malononitrile

: 456-48-4
3-Fluorobenzaldehyde

: 1443004-18-9
3-amino-1-(3-fluorophenyl)-5,10-dihydro-5,10-dioxo-1H-pyrazolo[1,2-b]phthalazine-2-carbonitrile

Guidance literature:: phthalic anhydride; With zinc(II) acetate dihydrate; hydrazine hydrate; In neat (no solvent); at 70 ℃; for 2h; Green chemistry;

malononitrile; 3-Fluorobenzaldehyde; In neat (no solvent); at 70 ℃; for 0.5h; Green chemistry;

Reference yield: 92.0%

: 136918-14-4,85-41-6
phthalimide

: 109-77-3
malononitrile

: 456-48-4
3-Fluorobenzaldehyde

: 1443004-18-9
3-amino-1-(3-fluorophenyl)-5,10-dihydro-5,10-dioxo-1H-pyrazolo[1,2-b]phthalazine-2-carbonitrile

Guidance literature:: With hydrazine hydrate; saccharin; In neat (no solvent); at 90 ℃; for 3h; Green chemistry;
DOI:10.1007/s13738-016-0871-5