methyl 3α-azido-7α-amino-12α-[N-(o-nitrobenzenesulfonyl)amino]-5β-cholan-24-oate

Base Information

• Chemical Name: methyl 3α-azido-7α-amino-12α-[N-(o-nitrobenzenesulfonyl)amino]-5β-cholan-24-oate
• CAS No.: 820216-78-2
• Molecular Formula: C₃₁H₄₆N₆O₆S
• Molecular Weight: 630.809

Synonyms:methyl 3α-azido-7α-amino-12α-[N-(o-nitrobenzenesulfonyl)amino]-5β-cholan-24-oate

Chemical Property of methyl 3α-azido-7α-amino-12α-[N-(o-nitrobenzenesulfonyl)amino]-5β-cholan-24-oate

Chemical Property:

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Technology Process of methyl 3α-azido-7α-amino-12α-[N-(o-nitrobenzenesulfonyl)amino]-5β-cholan-24-oate

There total 1 articles about methyl 3α-azido-7α-amino-12α-[N-(o-nitrobenzenesulfonyl)amino]-5β-cholan-24-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Nitrobenzenesulfonyl chloride (1694-92-4) + methyl 3α-azido-7α,12α-bis-amino-5β-cholan-24-oate (648928-61-4) → methyl 3α-azido-7α-amino-12α-[N-(o-nitrobenzenesulfonyl)amino]-5β-cholan-24-oate (820216-78-2) + methyl 3α-azido-12α-amino-7α-[N-(o-nitrobenzenesulfonyl)amino]-5β-cholan-24-oate + methyl 3α-azido-7α,12α-di[N-(o-nitrobenzenesulfonyl)amino]-5β-cholan-24-oate

Guidance literature:

With TEA; In tetrahydrofuran; at 20 ℃; for 12h; Further Variations:; Reagents; Product distribution;

DOI:10.1039/b412298d

Reference yield: 90.0%

methyl 3α-azido-7α-amino-12α-[N-(o-nitrobenzenesulfonyl)amino]-5β-cholan-24-oate (820216-78-2) + di-tert-butyl dicarbonate (24424-99-5) → methyl 3α-azido-12α-N-(o-nitrobenzenesulfonyl)amino-7α-[N-(t-butyloxycarbonyl)-amino]-5β-cholan-24-oate (820216-75-9)

Guidance literature:

With sodium hydrogencarbonate; In tetrahydrofuran; at 20 ℃; for 96h;

DOI:10.1039/b412298d

Reference yield: 83.0%

methyl 3α-azido-7α-amino-12α-[N-(o-nitrobenzenesulfonyl)amino]-5β-cholan-24-oate (820216-78-2) + Allyl chloroformate (2937-50-0) → methyl 3α-azido-12α-N-(o-nitrobenzenesulfonyl)amino-7α-[N-(allyloxycarbonyl)-amino]-5β-cholan-24-oate

Guidance literature:

With sodium hydrogencarbonate; In tetrahydrofuran; at 20 ℃; for 96h;

DOI:10.1039/b412298d

upstream raw materials:

2-Nitrobenzenesulfonyl chloride

methyl 3α-azido-7α,12α-bis-amino-5β-cholan-24-oate

Downstream raw materials:

methyl 3α-azido-12α-N-(o-nitrobenzenesulfonyl)amino-7α-[N-(t-butyloxycarbonyl)-amino]-5β-cholan-24-oate

(R)-4-{(3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-7-Amino-3-azido-12-[(S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-phenyl-propionylamino]-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl}-pentanoic acid methyl ester

(R)-4-{(3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-3-Azido-7-tert-butoxycarbonylamino-12-[(S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-phenyl-propionylamino]-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl}-pentanoic acid methyl ester

4-{3-amino-7-(2-tert-butoxycarbonylamino-3-methyl-butyrylamino)-12-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-phenyl-propionylamino]-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl}-pentanoic acid methyl ester

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