3-(4-phenyl-1-((tetrahydro-2H-pyran-2-yl)methyl)-1H-1,2,3-triazol-5-yl)phenol

Base Information

Chemical Name:3-(4-phenyl-1-((tetrahydro-2H-pyran-2-yl)methyl)-1H-1,2,3-triazol-5-yl)phenol
CAS No.:1477518-44-7
Molecular Formula:C₂₀H₂₁N₃O₂
Molecular Weight:335.406
Hs Code.:

Synonyms:3-(4-phenyl-1-((tetrahydro-2H-pyran-2-yl)methyl)-1H-1,2,3-triazol-5-yl)phenol

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Chemical Property of 3-(4-phenyl-1-((tetrahydro-2H-pyran-2-yl)methyl)-1H-1,2,3-triazol-5-yl)phenol

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Technology Process of 3-(4-phenyl-1-((tetrahydro-2H-pyran-2-yl)methyl)-1H-1,2,3-triazol-5-yl)phenol

There total 3 articles about 3-(4-phenyl-1-((tetrahydro-2H-pyran-2-yl)methyl)-1H-1,2,3-triazol-5-yl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₄H₁₆IN₃O

: 87199-18-6
3-hydroxyphenylboronic acid

: 1477518-44-7
3-(4-phenyl-1-((tetrahydro-2H-pyran-2-yl)methyl)-1H-1,2,3-triazol-5-yl)phenol

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; potassium hydroxide; In tetrahydrofuran; at 70 ℃; for 8h; Inert atmosphere;
DOI:10.2174/1386207311316080009

Reference yield:

: 181945-29-9
tetrahydropyranmethyl azide

: 1477518-44-7
3-(4-phenyl-1-((tetrahydro-2H-pyran-2-yl)methyl)-1H-1,2,3-triazol-5-yl)phenol

Guidance literature:: Multi-step reaction with 2 steps

1: Iodine monochloride; triethylamine; copper(l) chloride / tetrahydrofuran / 8 h / 20 °C / Inert atmosphere

2: bis-triphenylphosphine-palladium(II) chloride; potassium hydroxide / tetrahydrofuran / 8 h / 70 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; Iodine monochloride; triethylamine; copper(l) chloride; potassium hydroxide; In tetrahydrofuran; 1: |Huisgen Cycloaddition / 2: |Suzuki Coupling;
DOI:10.2174/1386207311316080009

Reference yield:

: 536-74-3
phenylacetylene

: 1477518-44-7
3-(4-phenyl-1-((tetrahydro-2H-pyran-2-yl)methyl)-1H-1,2,3-triazol-5-yl)phenol

Guidance literature:: Multi-step reaction with 2 steps

1: Iodine monochloride; triethylamine; copper(l) chloride / tetrahydrofuran / 8 h / 20 °C / Inert atmosphere

2: bis-triphenylphosphine-palladium(II) chloride; potassium hydroxide / tetrahydrofuran / 8 h / 70 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; Iodine monochloride; triethylamine; copper(l) chloride; potassium hydroxide; In tetrahydrofuran; 1: |Huisgen Cycloaddition / 2: |Suzuki Coupling;
DOI:10.2174/1386207311316080009