((2S,3S)-3-bromo-2-(4-chlorophenyl)-tetrahydro-2H-pyran-2-yl)-4-chlorophenylmethanone

Base Information

Chemical Name:((2S,3S)-3-bromo-2-(4-chlorophenyl)-tetrahydro-2H-pyran-2-yl)-4-chlorophenylmethanone
CAS No.:1307863-04-2
Molecular Formula:C₁₈H₁₅BrCl₂O₂
Molecular Weight:414.126
Hs Code.:

Synonyms:((2S,3S)-3-bromo-2-(4-chlorophenyl)-tetrahydro-2H-pyran-2-yl)-4-chlorophenylmethanone

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Chemical Property of ((2S,3S)-3-bromo-2-(4-chlorophenyl)-tetrahydro-2H-pyran-2-yl)-4-chlorophenylmethanone

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Technology Process of ((2S,3S)-3-bromo-2-(4-chlorophenyl)-tetrahydro-2H-pyran-2-yl)-4-chlorophenylmethanone

There total 4 articles about ((2S,3S)-3-bromo-2-(4-chlorophenyl)-tetrahydro-2H-pyran-2-yl)-4-chlorophenylmethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1307862-92-5
bis(4-chlorophenyl)(3,4-dihydro-2H-pyran-6-yl)methanol

: 1307863-04-2
((2S,3S)-3-bromo-2-(4-chlorophenyl)-tetrahydro-2H-pyran-2-yl)-4-chlorophenylmethanone

Guidance literature:: With hydroquinindine-2,5-diphenyl-4,6-pyrimidinediyl diether; (2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid; N-bromoacetamide; In tetrachloromethane; at 0 ℃; optical yield given as %ee; enantioselective reaction; Molecular sieve;
DOI:10.1021/ja201794v

Reference yield:

: 1307862-92-5
bis(4-chlorophenyl)(3,4-dihydro-2H-pyran-6-yl)methanol

: 1307863-04-2
((2S,3S)-3-bromo-2-(4-chlorophenyl)-tetrahydro-2H-pyran-2-yl)-4-chlorophenylmethanone

: 1307863-17-7
((2R,3R)-3-bromo-2-(4-chlorophenyl)-tetrahydro-2H-pyran-2-yl)-4-chlorophenylmethanone

Guidance literature:: With (8a,9R,8′′′a,9′′′R)-9,9′-[(2,5-diphenylpyrimidine-4,6-diyl)bis(oxy)]bis(6′-methoxy-10,11-dihydrocinchonan); (2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid; N-bromoacetamide; In tetrachloromethane; at 0 ℃; optical yield given as %ee; enantioselective reaction; Molecular sieve;
DOI:10.1021/ja201794v

Reference yield:

: 90-98-2
4,4'-Dichlorobenzophenone

: 1307863-04-2
((2S,3S)-3-bromo-2-(4-chlorophenyl)-tetrahydro-2H-pyran-2-yl)-4-chlorophenylmethanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 3 h / 0 - 20 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: hydroquinindine-2,5-diphenyl-4,6-pyrimidinediyl diether; (2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid; N-bromoacetamide / tetrachloromethane / 0 °C / Molecular sieve

With n-butyllithium; hydroquinindine-2,5-diphenyl-4,6-pyrimidinediyl diether; (2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid; N-bromoacetamide; In tetrahydrofuran; tetrachloromethane; hexane;
DOI:10.1021/ja201794v