4-methyl-3-oxo-7-phenyl-2-(2-triethylsiloxypropylidene)-hept-4-enenitrile

Base Information

Chemical Name:4-methyl-3-oxo-7-phenyl-2-(2-triethylsiloxypropylidene)-hept-4-enenitrile
CAS No.:479092-62-1
Molecular Formula:C₂₃H₃₃NO₂Si
Molecular Weight:383.606
Hs Code.:

Synonyms:4-methyl-3-oxo-7-phenyl-2-(2-triethylsiloxypropylidene)-hept-4-enenitrile

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Chemical Property of 4-methyl-3-oxo-7-phenyl-2-(2-triethylsiloxypropylidene)-hept-4-enenitrile

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Technology Process of 4-methyl-3-oxo-7-phenyl-2-(2-triethylsiloxypropylidene)-hept-4-enenitrile

There total 3 articles about 4-methyl-3-oxo-7-phenyl-2-(2-triethylsiloxypropylidene)-hept-4-enenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 109170-83-4
(S)-2-<(triethylsilyl)oxy>-2-propanal

: 4-methyl-3-oxo-7-phenyl-hept-4-enenitrile

: 479092-62-1
4-methyl-3-oxo-7-phenyl-2-(2-triethylsiloxypropylidene)-hept-4-enenitrile

Guidance literature:: With ethylenediamine diacetic acid; In benzene; at 20 ℃; for 3h;
DOI:10.1021/jo025641m

Reference yield:

: (S)-2-(triethylsilyloxy)propan-1-ol

: 479092-62-1
4-methyl-3-oxo-7-phenyl-2-(2-triethylsiloxypropylidene)-hept-4-enenitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 55 percent / Et₃N; DMSO; SO₃*pyridine / CH₂Cl₂ / 1.5 h / 0 °C

2: 86 percent / ethylenediammonium diacetate / benzene / 3 h / 20 °C

With pyridine-SO₃ complex; dimethyl sulfoxide; ethylenediamine diacetic acid; triethylamine; In dichloromethane; benzene; 2: Knoevenagel condensation;
DOI:10.1021/jo025641m

Reference yield:

: 905312-52-9
2-methyl-3-[(triethylsilyl)oxy]propionate methyl ester

: 479092-62-1
4-methyl-3-oxo-7-phenyl-2-(2-triethylsiloxypropylidene)-hept-4-enenitrile

Guidance literature:: Multi-step reaction with 3 steps

1: DIBAL-H / CH₂Cl₂; hexane / 2 h / -78 - 20 °C

2: 55 percent / Et₃N; DMSO; SO₃*pyridine / CH₂Cl₂ / 1.5 h / 0 °C

3: 86 percent / ethylenediammonium diacetate / benzene / 3 h / 20 °C

With pyridine-SO₃ complex; diisobutylaluminium hydride; dimethyl sulfoxide; ethylenediamine diacetic acid; triethylamine; In hexane; dichloromethane; benzene; 3: Knoevenagel condensation;
DOI:10.1021/jo025641m